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We present the detailed planning and execution of the Insight Toolkit (ITK), an application programmers interface (API) for the segmentation and registration of medical image data. This public resource has been developed through the NLM Visible Human Project, and is in beta test as an open-source software offering under cost-free licensing. The toolkit(More)
We report here the isolation and characterization of a cDNA that encodes a novel extracellular epidermal molecule, epidermal surface antigen (ESA), which is thought to play a role in intercellular epidermal adhesion. Sequence analysis reveals that the 379 amino acid ESA has a molecular mass of about 41.7 kDa and an alpha-helix-rich secondary conformation.(More)
Sustainable software ecosystems are difficult to build, and require concerted effort, community norms and collaborations. In science it is especially important to establish communities in which faculty, staff, students and open-source professionals work together and treat software as a first-class product of scientific investigation-just as mathematics is(More)
A repeat sequence 682 base pairs (bp) long produced by cleavage of human DNA with Xba I restriction enzyme is composed of four tandemly arranged subunits with lengths of 171, 170, 171, and 170 bp each. The sequence organization of the 682 bp Xba I repeat bears a striking resemblance to other complex satellite DNAs of primates, including the Eco RI human(More)
We observed the same task executed by 49 users on four production web sites. We tracked the rates of discovery of new usability problems on each site and, using that data, estimated the total number of usability problems on each site and the number of tests we would need to discover every problem. Our findings differ sharply from rules-of-thumb derived from(More)
A significant unsolved problem in scientific visualization is how to efficiently visualize extremely large time-varying datasets. Using parallelism provides a promising solution. One drawback of this approach is the high overhead and specialized knowledge often required to create parallel visualization programs. In this paper, we present a parallel(More)