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The reference sequence for each human chromosome provides the framework for understanding genome function, variation and evolution. Here we report the finished sequence and biological annotation of human chromosome 1. Chromosome 1 is gene-dense, with 3,141 genes and 991 pseudogenes, and many coding sequences overlap. Rearrangements and mutations of(More)
The genome sequence of the genetically tractable, mesophilic, hydrogenotrophic methanogen Methanococcus maripaludis contains 1,722 protein-coding genes in a single circular chromosome of 1,661,137 bp. Of the protein-coding genes (open reading frames [ORFs]), 44% were assigned a function, 48% were conserved but had unknown or uncertain functions, and 7.5%(More)
An approach to restriction-site mapping and contig building that uses fragment-size data from multiple complete digests of a set of clones that oversample a genomic region is presented. Maps containing both fragment-length data and clone-end data are maintained for each restriction enzyme. Synchronization between the maps for the different enzymes is(More)
This paper describes the philosophy and design of a specific course, Computer Science 236, taught over the past few years at Washington University. The philosophy of the course is that the objectives of the course can best be achieved by employing a series of associated projects which are complex enough to require a design and specification effort but are(More)
This paper describes components of an Interactive Program Advising System (IPAS) for beginning programming students. The system, being unaware of the algorithm being implemented by the student, is unable to direct the student toward writing a correct program. It instead comments on the programming constructs the student has used in the specific implementing(More)