Wilken Schuetz

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It was investigated whether adenosine affects the adenylate cyclase system of microvessels, isolated from the rat cerebral cortex, via an external receptor recently classified as R-site receptor. Several adenosine analogs caused GTP-dependent stimulation of adenylate cyclase. The rank order of potency: NECA (5'-(N-ethylcarboxamido)-adenosine, EC50 0.2(More)
The action of 1,3-dimethyl-5-aminoadamantane (DMAA, D-145, memantine, Memantine) on neurogenic bladder dysfunction in spastic conditions was investigated. Under memantine treatment micturition was considerably facilitated, and spontaneous, involuntary voiding reduced. Additionally, memantine effected a decrease of residual urine and toned down the vesicular(More)
The effects of an intracoronary aminophylline infusion, adjusted to give a constant concentration of 25 microgram.cm-3 coronary blood, on the reactive hyperaemic responses following coronary occlusion for 4, 10, and 25 heart beats were investigated in anaesthetised, open-chest dogs. The vasodilator effect of intracoronarily-administered adenosine and the(More)
Nowadays, many configurable products and services are sold via web. For supporting a customer in configuring the desired product, the interaction with the configurator has to be personalised according to the user's interests. In this paper, we show how these interests can be estimated. In an idealisation, we ascribe the Multi-Attribute Utility Theory as(More)
Dopamine-stimulated adenylyl cyclase activity was measured in striatal homogenates of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated rhesus monkeys and humans with idiopathic Parkinson's disease and compared with the activity in control tissue. No differences between parkinsonian and control tissue were found in the presence of 20 mM NaCl.(More)
Within CAWICOMS a configuration workbench for customisable products and services will be developed which will have the following advantages versus current commercially available configuration technology: It will automate over the Web the skills of salespersons by developing adaptation and personalisation technology for inclusion in Web based configurators.(More)
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