Wilfried Andrä

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PURPOSE To assess relevant parameters for the minimally invasive elimination of breast tumors by using a selective application of magnetite and exposure of the breast to an alternating magnetic field. MATERIALS AND METHODS The specific absorption rate (SAR) of different magnetite samples was determined calorimetrically. Temperature elevations based on(More)
RATIONALE AND OBJECTIVES The biologic effects of magnetically induced heating effects using iron oxide, magnetite, were examined in vitro in liver tissue samples as a first step toward potential applications in cancer therapy. METHODS For the determination of the temperature profile around an iron oxide sample, a cylinder containing 170 mg of magnetite(More)
In internal medicine, a simple method for the functional examination of the gastrointestinal tract without the risk of radiation exposure is required. We describe a novel principle based on the monitoring of magnetic markers which meets these demands. Our method employs a special permanent magnet which is repeatedly aligned by a vertically oriented pulsed(More)
In contrast to the well-developed methods for morphological diagnosis of the gastrointestinal tract, there is no comparatively satisfying technique for functional disorders. One important example is irritable bowel syndrome (IBS), a disorder that affects a high percentage of all individuals. It can only be diagnosed by excluding organic diseases and by(More)
The therapeutic strategy for breast cancer is changing, especially for early tumor stages with good prognosis. One potential minimally invasive therapy modality consists in the accumulation of a well-tolerated magnetic material (iron oxides, particularly magnetite) in the target tissue. By applying an alternating magnetic field, energy is selectively(More)
RATIONALE AND OBJECTIVES In addition to their diagnostic applications, iron oxides could be used therapeutically to eliminate tumors with heat if their heating powers are adequate. The authors therefore examined the specific absorption rate (SAR) of different iron oxide (magnetite) samples suspended in water and in liquid or solidified gel. MATERIALS AND(More)
Optimal conditions for removing leukemic cells from human bone marrow with monoclonal antibodies (mAb) and magnetic immunobeads were investigated. Monodisperse 3 microns polystyrene microspheres containing magnetite were coated with affinity-purified rabbit antimouse IgG at 4 degrees C, pH 9.6 for 18 h. SKW-3 cells (T-CLL cell line) were marked with the(More)
Epitaxial magnetite thin films with (loo), (1 10) and (1 11) orientation have been deposited by Laser ablation onto substrates with [NaCI] and [Spinel] strudure. X-ray dif£raction revealed pseudomorphic growth for (100) and (11 1) oriented films on MgO (100) and ZnFe,04 (1 11) respectively, whereas films on M&04 showed a high degree of relaxation For films(More)
PURPOSE To find an optimal imaging modality for the assessment of magnetite agglomerations used as the heating sources during magnetic thermoablation of tumors. METHODS 1 to 107 mg of coated (starch) magnetite particles were directly administered to an in vitro tumor model (swine lymph nodes) and investigated immediately (radiography) or after being(More)