Wilfred Li

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Apoptosis research has been significantly aided by the generation of antibodies against caspase-cleaved peptide neo-epitopes. However, most of these antibodies recognize the N-terminal fragment and are specific for the protein in question. The aim of this project was to create antibodies, which could identify caspase-cleaved proteins without a priori(More)
1. Abstract Neuraminidase is a key target protein for the development of antiviral drugs. This study proposes and investigates a scaffold-based, fragment-growing method to identify novel molecular scaffolds for Group 1 neuraminidase inhibition. In addition to re-identifying the scaffolds of known hits, this study identifes adamantane (C10H16) as a new,(More)
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