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- Ruben L. Smeets, Wilco W. M. Fleuren, +10 authors Wynand Alkema
- BMC Immunology
- 2011
BackgroundT lymphocytes are orchestrators of adaptive immunity. Naïve T cells may differentiate into Th1, Th2, Th17 or iTreg phenotypes, depending on environmental co-stimulatory signals. To identify… (More)
- Wilco W. M. Fleuren, Stefan Verhoeven, +5 authors Wynand Alkema
- Nucleic Acids Research
- 2011
In this article, we present CoPub 5.0, a publicly available text mining system, which uses Medline abstracts to calculate robust statistics for keyword co-occurrences. CoPub was initially developed… (More)
- Raoul Frijters, Wilco W. M. Fleuren, +8 authors Wynand Alkema
- BMC Genomics
- 2010
BackgroundGlucocorticoids (GCs) control expression of a large number of genes via binding to the GC receptor (GR). Transcription may be regulated either by binding of the GR dimer to DNA regulatory… (More)
- Wilco W. M. Fleuren, Wynand Alkema
- Methods
- 2015
In recent years the amount of experimental data that is produced in biomedical research and the number of papers that are being published in this field have grown rapidly. In order to keep up to date… (More)
- Marijn P. A. Sanders, Wilco W. M. Fleuren, +4 authors Jan P. G. Klomp
- BMC Bioinformatics
- 2010
BackgroundG-protein coupled receptors (GPCRs) are involved in many different physiological processes and their function can be modulated by small molecules which bind in the transmembrane (TM)… (More)
- Erik J. M. Toonen, Wilco W. M. Fleuren, +4 authors Wynand Alkema
- Pharmacogenomics
- 2011
BACKGROUND
Prednisolone and other glucocorticoids (GCs) are potent anti-inflammatory and immunosuppressive drugs. However, prolonged use at a medium or high dose is hampered by side effects of which… (More)
- Wilco W. M. Fleuren, Erik J. M. Toonen, +6 authors Wynand Alkema
- BioData Mining
- 2012
BackgroundGlucocorticoids are potent anti-inflammatory agents used for the treatment of diseases such as rheumatoid arthritis, asthma, inflammatory bowel disease and psoriasis. Unfortunately, usage… (More)
- Wilco W. M. Fleuren, Margot M Linssen, +6 authors Wynand Alkema
- Archives of physiology and biochemistry
- 2013
Synthetic glucocorticoids are potent anti-inflammatory drugs but show dose-dependent metabolic side effects such as the development of insulin resistance and obesity. The precise mechanisms involved… (More)
- Sandrine Ellero-Simatos, Wilco W. M. Fleuren, Susanne Bauerschmidt, Wim H. A. Dokter, Erik J. M. Toonen
- Pharmacogenomics
- 2014
BACKGROUND
Prednisolone is a potent anti-inflammatory glucocorticoid (GC) but chronic use is hampered by metabolic side effects. Little is known about the long-term effects of GCs on gene-expression… (More)