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The pathogenesis of classical Hodgkin lymphoma (cHL) involves environmental and genetic factors. To explore the role of the human leukocyte antigen (HLA) genes, we performed a case-control genotyping study in 338 Dutch cHL patients using a PCR-based sequence-specific oligonucleotide probe (SSOP) hybridization approach. The allele frequencies were compared(More)
BACKGROUND In Caucasian populations, the tumor cells of Epstein Barr virus (EBV)-positive classical Hodgkin Lymphomas (cHL) patients more frequently express HLA class I and HLA class II molecules compared to EBV-negative cHL patients. HLA expression (in relation to EBV) in Asian cHL patients has not been previously investigated. METHODOLOGY/PRINCIPAL(More)
Chronic obstructive pulmonary disease (COPD) is an inflam-matory disorder of structural airway cells with cigarette smoke as the main etiologic factor. COPD patients are treated with agonists of the β 2-adrenoceptor, which induce their biological effects by elevating cyclic AMP and subsequently activate protein kinase A (PKA) and the " exchange proteins(More)
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