Wiek H. van Gilst

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The (pro)renin-renin receptor [(P)RR] was discovered as an important novel component of the renin-angiotensin system (RAS). The functional significance of (P)RR is widely studied in renal and vascular pathologies and has sparked interest for a potential role in cardiovascular disease. To investigate the role of (P)RR in cardiac pathophysiology, we aimed to(More)
Pathological cardiac hypertrophy is characterized by a shift in metabolic substrate utilization from fatty acids to glucose, but the molecular events underlying the metabolic remodeling remain poorly understood. Here, we investigated the role of liver X receptors (LXRs), which are key regulators of glucose and lipid metabolism, in cardiac hypertrophic(More)
D ifferential localisation of the renin–angiotensin system in de-novo lesions and in-stent restenotic lesions in in-vivo human coronary arteries a a b a Abstract Objective: Different components of the renin–angiotensin system (RAS) have been demonstrated in atherosclerotic plaques. However, the involvement of the RAS in in-stent restenosis is not clear. We(More)
Chapter 4 50 The present study aimed to examine the effects of long-term treatment with the angiotensin-converting-enzyme-inhibitor quinapril on markers of inflammation in patients requiring coronary artery bypass grafting. We performed a subgroup analysis of a prospective, placebo-controlled , randomized, multi-center study evaluating quinapril 40 mg. once(More)
Restenosis after balloon angioplasty is a serious clinical problem arising in cardiology. Restenosis is caused by the induction of uncontrolled proliferation of vascular smooth muscle cells following damage of the endothelial lining of the vessel by balloon dilation. A gene therapy approach may provide the means to control the mechanisms responsible for(More)
Background: Activation of the endothelin system is an important compensatory mechanism that is activated during left ventricular dysfunction. Whether this system also plays a role at the atrial level during AF has not been thoroughly examined. The purpose of this study was to investigate mRNA and protein expression levels of the endothelin system in AF(More)
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