Wiek H. van Gilst

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Aims: Besides stimulating hematopoiesis, erythropoietin (EPO) protects against experimental ischemic injury in the heart. The present study evaluated the safety and tolerability of EPO treatment in non-anemic patients with acute myocardial infarction (MI). Methods and Results: In this single-center, investigator-initiated, prospective study, patients with a(More)
Angiotensin (Ang) II is a key player in left ventricular (LV) remodeling and cardiac fibrosis. Its effects are thought to be transferred at least in part by mitogen-activated protein kinases (MAPK), transforming growth factor (TGF) β1, and the Smad pathway. In this study we sought to elucidate whether Ang II related effects on LV dysfunction and fibrosis in(More)
Angiotensin-converting enzyme (ACE) activation and the de novo production of angiotensin II contribute to cardiovascular disease through direct pathological tissue effects, including vascular remodeling and inflammation, as well as indirect action on nitric oxide bioavailability and its consequences. The endothelium plays a pivotal role in both vascular(More)
Pathological cardiac hypertrophy is characterized by a shift in metabolic substrate utilization from fatty acids to glucose, but the molecular events underlying the metabolic remodeling remain poorly understood. Here, we investigated the role of liver X receptors (LXRs), which are key regulators of glucose and lipid metabolism, in cardiac hypertrophic(More)
Pieter J. de Kam, MSC,* Adriaan A. Voors, MD, PHD,†‡ Maarten P. van den Berg, MD, PHD,* Dirk J. van Veldhuisen, MD, PHD, FACC,* Jan Brouwer, MD, PHD,* Harry J. G. M. Crijns, MD, PHD,* Claudio Borghi, MD,§ Ettore Ambrosioni, MD,§ Judith S. Hochman, MD,\ Thierry H. LeJemtel, MD,¶ Jan-Herre Kingma, MD, PHD,† Martin St. John Sutton, MD, MBBS, FACC,# Wiek H. van(More)
We aimed to evaluate whether ischemia is required for erythropoietin (EPO) induced stimulation of endothelial progenitor cells (EPCs) and their related effects on endothelial and cardiac function. Bone marrow of rats was replaced by transgenic cells to allow tracking of EPCs. Ischemic heart failure was induced by left coronary artery ligation to induce(More)
Contrast microbubbles in combination with ultrasound (US) are promising vehicles for local drug and gene delivery. However, the exact mechanisms behind intracellular delivery of therapeutic compounds remain to be resolved. We hypothesized that endocytosis and pore formation are involved during US and microbubble targeted delivery (UMTD) of therapeutic(More)
The QUO VADIS (the effects of QUinapril On Vascular Ace and Determinants of ISchemia) study was a randomized, double-blind, placebo-controlled trial designed to evaluate the effects of long-term angiotensin-converting enzyme (ACE) inhibition on angiotensin II formation in human vasculature. Patients (n < 187) scheduled for coronary artery bypass surgery(More)
Introduction: Ventricular remodeling starts very early after the onset of an acute myocardial infarction (AMI), and can be prevented by ACE-inhibitors. However, very limited data are available on the effect of acute (< 9 hours) treatment with angiotensin converting enzyme (ACE) inhibitors after an AMI on mortality, heart failure and re-infarction. The aim(More)
Drug Utilization Research and Pharmacoepidemiology Meeting U t r e c h t ( T h e N e t h e r l a n d s ) , 19 M a y 1995 Organized by the Section of Drug Utilization and Pharmacoepidemiology of the Dutch Society of Pharmaceutical Sciences (Sectie Geneesmiddelengebruiksonderzoek en Farmacoepidemiologie van de Nederlandse Vereniging voor Farmaceutische(More)