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Transforming growth factor-beta induces development of the T(H)17 lineage.
TLDR
Transforming growth factor-beta (TGF-beta) is identified as a cytokine critical for commitment to T(H)17 development and acts to upregulate IL-23R expression, thereby conferring responsiveness to IL- 23.
Transforming growth factor-β induces development of the TH17 lineage
TLDR
Transforming growth factor-β (TGF-β) is identified as a cytokine critical for commitment to TH17 development and provides a mechanism for divergence of the TH1, TH2 and TH17 lineages.
Contrasting roles for all-trans retinoic acid in TGF-β–mediated induction of Foxp3 and Il10 genes in developing regulatory T cells
TLDR
At-RA has reciprocal effects on the induction of Foxp3 and Il10 in developing CD4+ T reg cells and it is suggested that TLR9-dependent inhibition of at-RA production by antigen-presenting cells might represent one mechanism to promote the development of IL-10–expressing T cells.
Gα13 Mediates a Signal That Is Essential for Proliferation and Survival of Thymocyte Progenitors
TLDR
Overexpression of the antiapoptotic gene Bcl2 rescued the defect in DN3 cells and partially rescued T cell development and demonstrated that Gα13-mediated signaling is necessary in early thymocyte proliferation and survival.
RhoA biological activity is dependent on prenylation but independent of specific isoprenoid modification.
TLDR
Cells expressing farnesylated RhoA retained sensitivity to the growth inhibition caused by inhibition of geranylgeranyltransferase I, indicating that other proteins are critical targets for inhibitors of Geranylgeranylation.
Modulation of NFAT‐dependent gene expression by the RhoA signaling pathway in T cells
TLDR
RhoA is able to inhibit HIV‐1 gene expression through the NFAT‐binding site in the HIV long‐terminal repeat and activation of RhoA can modulateIL‐2 gene expression by inhibiting the transcriptional activity of NFAT and chromatin structure at the IL‐2 promoter during T cell activation.
Delayed functional maturation of natural regulatory T cells in the medulla of postnatal thymus: role of TSLP
TLDR
Expression of FoxP3 or Treg maturation is ontogenically distinct and kinetically delayed from the generation of CD4+CD8-CD25+ or CD4-CD8 -CD25- thymocytes in the postnatal thymus, suggesting that the development of Treg cells requires paracrine signaling during late stages of thymocyte maturation that is distinct from signaling during positive or negative selection.