Whitney L Ducaine

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UNLABELLED Advances in genetics have prompted recommendations that all healthcare providers perform genetic counseling and testing. Some experts are concerned about potential negative outcomes from cancer genetic testing performed without genetic counseling by certified genetics professionals. We report a national series of cases illustrating negative(More)
We report a case of a client who discovered she had a BRCA mutation following direct-to-consumer (DTC) genetic testing in the absence of genetic counseling. After testing she presented for genetic counseling with anxiety, distress, and a deficit of knowledge about what the DTC genetic testing revealed. Genetic counseling helped alleviate distress while(More)
After repeated media attention in 2013 due to the Angelina Jolie disclosure and the Supreme Court decision to ban gene patents, the demand for cancer genetic counseling and testing services has never been greater. Debate has arisen regarding who should provide such services and the quality of genetics services being offered. In this ongoing case series, we(More)
Background Hereditary Breast and Ovarian Cancer (HBOC) syndrome due to mutations in BRCA1 and BRCA2 is associated with an increase in risk for primarily breast cancer and ovarian cancer. Lynch syndrome (LS), due to mutations in MLH1, MSH2, MSH6, and PMS2 is typically associated with an increase in risk for chiefly colorectal cancer and endometrial cancer.(More)
Background Lynch syndrome (LS) is responsible for around 2-3% of all colorectal cancers [1]. Germline mutations within one of four mismatch repair (MMR) genes, MLH1, MSH2, MSH6, or PMS2, cause an increased risk in colorectal, endometrial, urinary tract, and other cancers. Tumor screening, by microsatellite instability (MSI) and immunohistochemistry (IHC)(More)
Selected abstracts submitted to the Third International Symposium on Hereditary Breast and Ovarian Cancer BRCA: Fifteen Years of Progress, Third International Symposium on Hereditary Breast and Ovarian Cancer; October 14–16, 2009; Centre Mont-royal, Montreal, Quebec, Canada The opinions expressed in the abstracts are those of the authors and are not to be(More)
1596 Background: Magnetic resonance imaging (MRI) is the preferred imaging modality for screening and diagnosis of breast cancer in BRCA-1and BRCA-2 mutation carriers. However, there is limited data on the radiographic features of BRCA1/2-positive breast cancers on MRI. This study evaluates the MRI characteristics of BRCA1/2 -related breast cancers. (More)
Background Lynch syndrome (LS) is a genetic disorder that accounts for approximately 3% of all colorectal cancers (CRC) [1]. Clinical characteristics of LS include proximal CRC, multiple CRCs, occurrence at a young age, accelerated carcinogenesis, and an increase in risk of extracolonic cancers [1]. LS is an autosomal dominant disorder, caused by germline(More)
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