Whei-meih Chang

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Drug design is the approach of finding drugs by design using computational tools. When designing a new drug, the structure of the drug molecule can be modeled by classification of potential chemical compounds. Kernel Methods have been successfully used in classifying chemical compounds, within which the most popular one is Support Vector Machine (SVM). In(More)
Xenoestrogens can interfere with normal estrogen signaling by competitively binding to the estrogen receptor (ER) and activating transcription of target genes. In this study, we cloned the estrogen receptor alpha (vbERalpha) and beta 2 (vbERbeta2) genes from liver of the indigenous Taiwanese cyprinid fish Varicorhinus barbatulus and tested the direct impact(More)
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