Wesley L. Lin

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Solamargine, an herbal and molluscicidal medicine derived from Solanum incanum, is a steroidal alkaloid glycoside. To characterize the anticancer mechanism of solamargine on human hepatoma cells (Hep3B), changes of cell morphology, DNA content, and gene expression of cells after solamargine treatment were studied. The appearance in solamargine-treated cells(More)
PURPOSE Previous gene transfection studies have shown that the accumulation of human ribonucleotide reductase small subunit M2 (hRRM2) enhances cellular transformation, tumorigenesis, and malignancy potential. The latest identified small subunit p53R2 has 80% homology to hRRM2. Here, we investigate the role of p53R2 in cancer invasion and metastasis. (More)
To conciliate scaling-driven fundamental material limitations with industry evolution requirements, flexible CMOS technologies and tighter interaction between process development and circuit/system design are needed to efficiently realize systems on a chip (SoC). This paper discusses issues associated with power supply scaling, performance-leakage power(More)
Activation of Hypoxia-Inducible Factor-1 Is Necessary for Lysophosphatidic Acid–Induced Vascular Endothelial Growth Factor Expression. Jangsoon Lee, Soon Young Park, Eun Kyung Lee, Chang Gyo Park, Hyun Cheol Chung, Sun Young Rha, Yong Kee Kim, Gyu-Un Bae, Bum Kyeong Kim, Jeung-Whan Han, and Hoi Young Lee(More)
PURPOSE To develop a novel reconstruction method for X-ray CT that can lead to accurate reconstruction at significantly reduced dose levels combining low X-ray incident intensity and few views of projection data. METHODS The noise nature of the projection data at low X-ray incident intensity was modeled and accounted by the weighted least-squares (WLS)(More)
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