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  • Jeffrey M. Witkin, Carl D. Overshiner, +10 authors Christian C. Felder
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 2014 (First Published: 1 November 2014)
  • Scopolamine produces rapid and significant symptom improvement in patients with depression, and most notably in patients who do not respond to current antidepressant treatments. Scopolamine is aContinue Reading
  • K. A. Stefan Svensson, Beverly A. Heinz, +29 authors Robert F. Bruns
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 2017
  • Allosteric potentiators amplify the sensitivity of physiologic control circuits, a mode of action that could provide therapeutic advantages. This hypothesis was tested with the dopamine D1 receptorContinue Reading
  • Bernard M. McGarvey, Nancy J. Dynes, Burch C. Lin, Wesley H. Anderson, James P. Kremidas, James C. Felli
  • Computer Science
  • Winter Simulation Conference
  • 2007 (First Published: 9 December 2007)
  • Clinical trials constitute large, complex, and resource intensive activities for pharmaceutical companies. Accurate prediction of patient enrollment would represent a major step forward in optimizingContinue Reading
  • Scott D. Gleason, Akihiko Kato, +8 authors Jeffrey M. Witkin
  • Biology, Medicine
  • CNS & neurological disorders drug targets
  • 2015 (First Published: 31 May 2015)
  • Transmembrane AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor regulatory protein (TARP) γ-8 is an auxiliary protein associated with some AMPA receptors. Most strikingly, AMPAContinue Reading