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Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice.
RATIONALE The NF-E2 related factor 2 (Nrf2)-antioxidant response element (ARE) pathway is essential for protection against oxidative injury and inflammation including hyperoxia-induced acute lungExpand
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Quantitative trait loci associated with maximal exercise endurance in mice.
The role of genetics in the determination of maximal exercise endurance is unclear. Six- to nine-week-old F2 mice (n = 99; 60 female, 39 male), derived from an intercross of two inbred strains thatExpand
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Lactoferrin gene expression is estrogen responsive in human and rhesus monkey endometrium.
We have previously shown that the estrogen responsiveness of the human lactoferrin gene in a transient transfection system is mediated through an imperfect estrogen response element (ERE) and aExpand
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Targeted deletion of nrf2 impairs lung development and oxidant injury in neonatal mice.
AIMS Nrf2 is an essential transcription factor for protection against oxidant disorders. However, its role in organ development and neonatal disease has received little attention. TherapeuticallyExpand
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Exacerbated Airway Toxicity of Environmental Oxidant Ozone in Mice Deficient in Nrf2
Ozone (O3) is a strong oxidant in air pollution that has harmful effects on airways and exacerbates respiratory disorders. The transcription factor Nrf2 protects airways from oxidative stress throughExpand
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Estrogen stimulates estrogen-related receptor alpha gene expression through conserved hormone response elements.
The estrogen-related receptor alpha gene encodes a nuclear receptor protein, ERR alpha, whose structure is closely related to the estrogen receptors. ERR alpha modulates estrogen receptorExpand
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Differential Expression and Estrogen Response of Lactoferrin Gene in the Female Reproductive Tract of Mouse, Rat, and Hamster
Abstract Lactoferrin, an iron-binding glycoprotein, kills bacteria and modulates inflammatory and immune responses. Presence of lactoferrin in the female reproductive tract suggests that the proteinExpand
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Vanadium stimulates human bronchial epithelial cells to produce heparin-binding epidermal growth factor-like growth factor: a mitogen for lung fibroblasts.
The bronchial epithelium is a potential source of growth factors that could mediate airway fibrosis during the progression of diseases such as asthma and chronic bronchitis. We report thatExpand
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Methylation and expression of the lactoferrin gene in human tissues and cancer cells
The lactoferrin gene promoter contains GC-rich regions that harbor consensus sequences for a variety of transcription factors. Previous work in our laboratory has demonstrated a link betweenExpand
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Single nucleotide polymorphisms (SNPs) in human lactoferrin gene.
  • C. Teng, W. Gladwell
  • Medicine, Biology
  • Biochemistry and cell biology = Biochimie et…
  • 27 April 2006
The lactoferrin protein possesses antimicrobial and antiviral activities. It is also involved in the modulation of the immune response. In a normal healthy individual, lactoferrin plays a role in theExpand
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