Wesley D. Gilson

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OBJECTIVE Normative apparent diffusion coefficient (ADC) and fractional anisotropy (FA) metrics of the brain have been published previously. However, no larger studies evaluated the normal evolution of ADC/FA metrics of the maturing paediatric spinal cord. Goal of this study is to evaluate the age-dependent evolution of the ADC/FA values of the(More)
Displacement-encoded imaging with stimulated echoes (DENSE) and harmonic phase imaging (HARP) employ 1-1 spatial modulation of magnetization to cosine modulate the longitudinal magnetization as a function of position at end diastole. Later in the cardiac cycle they sample the cosine-modulated signal and compute myocardial strain from the signal phase. The(More)
The purpose of this study was to use MR myocardial tagging to assess regional cardiac function after myocardial infarction (MI) in mice. Eight mice were imaged before and 1 day after MI. MRI included cine imaging, myocardial tagging, and contrast-enhanced imaging. Regional percent circumferential shortening (%CS) was measured from the tagged images, and the(More)
In proton magnetic resonance imaging (MRI) metallic substances lead to magnetic field distortions that often result in signal voids in the adjacent anatomic structures. Thus, metallic objects and superparamagnetic iron oxide (SPIO)-labeled cells appear as hypointense artifacts that obscure the underlying anatomy. The ability to illuminate these structures(More)
MRI is emerging as an important modality for assessing myocardial function in transgenic and knockout mouse models of cardiovascular disease, including myocardial infarction (MI). Displacement encoding with stimulated echoes (DENSE) measures myocardial motion at high spatial resolution using phase-reconstructed images. The current DENSE technique uses(More)
In displacement-encoded imaging with stimulated echoes (DENSE), tissue displacement is encoded in the phase of the stimulated echo. However, three echoes generally contribute to the acquired signal (the stimulated echo, the complex conjugate of the stimulated echo, and an echo due to T(1) relaxation). It is usually desirable to suppress all except the(More)
A black blood gradient echo sequence for multiphase cardiac MRI of the mouse heart was implemented on a 4.7-T scanner and compared to a conventional bright blood sequence. Black blood was achieved using the double inversion recovery technique. Ten mice were imaged using both the bright and the black blood sequences, and 2 of the mice were additionally(More)
A new technique was developed to increase the signal-to-noise ratio (SNR) in displacement encoding with stimulated echoes (DENSE) MRI. This signal-averaged DENSE (sav-DENSE) technique is based on the SNR advantage of extracting a pair of DENSE images with uncorrelated noise from the complex complementary spatial modulation of the magnetization image, and(More)
Image guided interventions often involve C-arm X-ray imaging systems. State-of-the art fluoroscopy systems not only offer 2-D X-ray imaging, but they can also be used to obtain 3-D cone-beam tomo-graphic data sets. These 3-D volumetric images can be used for image guidance and device navigation. To navigate a device with confidence, it is, however,(More)
This study evaluated the utility of cardiac MRI for assessing the impact of myocardial infarction (MI) on cardiac structure and function in mice following reperfused 1- or 2-hr occlusions of the left anterior descending coronary artery (LAD). When assessed 1 day after MI, the left ventricular ejection fraction (LVEF) had declined by more than half, and(More)