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Light-activated Cre recombinase as a tool for the spatial and temporal control of gene function in mammalian cells.
Tight spatio-temporal control over DNA recombination is achieved by the installation of a light-responsive o-nitrobenzyl caging group directly in the catalytic site of Cre, inhibiting its activity.
Light-triggered polymerase chain reaction.
- D. Young, Wesleigh F. Edwards, H. Lusic, M. Lively, A. Deiters
- Biology, ChemistryChemical communications
- 10 January 2008
Photochemical control of the polymerase chain reaction has been achieved through the incorporation of light-triggered nucleotides into DNA.
Influence of peripheral hydrogen bonding on the mechanical properties of photo-cross-linked star-shaped poly(D,L-lactide) networks.
- Afia S. Karikari, Wesleigh F. Edwards, J. Mecham, T. Long
- Materials ScienceBiomacromolecules
- 19 August 2005
The introduction of terminal hydrogen-bonding sites that were adjacent to the photo-cross-linking site resulted in higher performance poly(lactide)-based bioadhesives.
The effect of microwave irradiation on DNA hybridization.
Observations indicate a specific interaction of microwaves with DNA, and have important implications in the chemical or enzymatic processing of DNA under microwave heating.
Comparative Effectiveness of Venetoclax Combinations Vs Other Therapies Among Patients with Newly Diagnosed Acute Myeloid Leukemia: Results from the AML Real World Evidence (ARC) Initiative
The authors explored real-world practices and clinical outcomes of patients (pts) treated with VEN-based vs. non-VEN-based regimens in the AML Real world evidenCe (ARC) Initiative and found that across subgroups, TP53 mutation was present in higher proportions of VEN pts compared to control.
Delivering bad news in amyotrophic lateral sclerosis: Proposal of a specific technique ALS ALLOW
An ALS-specific technique is proposed which is called ALS ALLOW to guide physicians in conducting difficult communications with ALS patients and caregivers to develop their understanding, establish autonomy, set goals, and mitigate emotional trauma.
Characteristics and Outcomes of Newly Diagnosed Acute Myeloid Leukemia Patients Receiving Venetoclax Combinations Vs Other Therapies: Results from the AML Real World Evidence (ARC) Initiative
The AML Real world evidenCe (ARC) Initiative provides insight into the characteristics and outcomes of ND AML patients (pts) treated with VEN combinations vs non-VEN-based regimens in clinical practice, with a targeted sample size of over 500 pts.
GNAQ R183Q Mutation Identified in a Young Patient with Uveal Melanoma, Ocular Surface Melanosis, and Nevus of Ota
Real-World Management of Patients with Newly Diagnosed Acute Myeloid Leukemia Treated with Venetoclax-Based Regimens: Results from the AML Real World Evidence (ARC) Initiative
The AML Real world evidenCe Initiative is a multicenter chart review study of adult pts with ND AML treated with VEN-based regimens and matched control pts (by age and ELN risk) from different academic sites in the US and Israel, assessing real-world outcomes as well as VEN treatment practices.