Werner Schmitz

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BACKGROUND Transforming growth factor (TGF)beta superfamily members transduce signals by oligomerizing two classes of serine/threonine kinase receptors, termed type I and type II. In contrast to the large number of ligands only seven type I and five type II receptors have been identified in mammals, implicating a prominent promiscuity in ligand-receptor(More)
The mitochondrial beta-oxidation system is one of the central metabolic pathways of energy metabolism in mammals. Enzyme defects in this pathway cause fatty acid oxidation disorders. To elucidate the role of 2,4-dienoyl-CoA reductase (DECR) as an auxiliary enzyme in the mitochondrial beta-oxidation of unsaturated fatty acids, we created a DECR-deficient(More)
  • M Adamus, I V Ajinenko, +41 authors S A Zotkin
  • 2007
Two-pion correlations are studied for pions of like charge in K + p and + p collisions at 250 GeV/c. An enhanced production is observed at small momentum diierence and is attributed to Bose-Einstein interference between identical particles. A systematic study is presented on the innuence of parametrization and reference sample. Interpreted in terms of the(More)
Deregulated expression of MYC is a driver of colorectal carcinogenesis, necessitating novel strategies to inhibit MYC function. The ubiquitin ligase HUWE1 (HECTH9, ARF-BP1, MULE) associates with both MYC and the MYC-associated protein MIZ1. We show here that HUWE1 is required for growth of colorectal cancer cells in culture and in orthotopic xenograft(More)
Cross sections are presented for the inclusive production of charged particles measured in electron-proton collisions at low Q 2 with the H1 detector at HERA. The transverse momentum distribution extends up to 8 GeV/c. Its shape is found to be harder than that observed in pp collisions at comparable centre-of-mass energies p s p p s pp 200 GeV, and also(More)
Global properties of the hadronic nal state in deep inelastic scattering events at HERA are investigated. The data are corrected for detector eeects and are compared directly with QCD phenomenology. Energy ows in both the laboratory frame and the hadronic centre of mass system and energy-energy correlations in the laboratory frame are presented. Comparing(More)
  • Aachen-Antwerp, Brussels-Berlin, +44 authors S A Zotkin
  • 2007
Forward-backward multiplicity correlations in + p, K + p and pp collisions at 250 GeV/c (p s=22 GeV) are given for all charges and for the diierent charge combinations. The correlations are found to be caused predominantly by centrally produced particles. It is demonstrated that this result is in agreement with observations at the ISR and the CERN p(More)
The average transverse momentum hp T i has been studied as a function of the charge multiplicity n in + p, K + p and pp collisions at 250 GeV/c (p s 22 GeV) and compared to that at other energies. The eeect of cuts in rapidity and p T is demonstrated. A comparison to currently used low-p T models shows that the two-chain Dual Parton Model underestimates the(More)
  • Aachen-Antwerp, Brussels-Berlin, +50 authors Switzerland
  • 2007
The charged particle multiplicity distribution has been studied for non-single-diiractive + p and pp collisions at p s = 22 GeV, for full phase space as well as for intervals in rapidity, azimuthal angle and transverse momentum. In general, the multiplicity distribution is well described by a negative binomial. From comparison of the distribution for(More)