Werner Schaefer

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PURPOSE We investigated the relationship between experimental neuroimaging and self-reported urinary incontinence measures. MATERIALS AND METHODS We evaluated 14 functionally independent, community dwelling women older than 60 years with moderate to severe urgency urinary incontinence. All underwent detailed clinical assessment (3-day bladder diary,(More)
AIM To identify age-related changes in the normal brain/bladder control system, and differences between urge incontinence in younger and older women, as shown by brain responses to bladder filling; and to use age, bladder volume, urge incontinence and detrusor overactivity (DO) as probes to reveal control system function. Functional MRI was used to examine(More)
Loss of bladder control (urge incontinence) is common in elderly; the cause is usually unknown. Functional imaging has revealed the brain network controlling responses to bladder filling. Age-related changes in this network might predispose to urge incontinence. We sought such changes in 10 continent, healthy women aged 30-79 years who underwent fMRI while(More)
Evidence from longitudinal studies in community-dwelling elderly links complaints of urgency and urinary incontinence with structural white matter changes known as white matter hyperintensities (WMH). How WMH might lead to incontinence remains unknown, since information about how they relate to neural circuits involved in continence control is lacking. The(More)
The regions of the supraspinal network that controls urinary bladder behavior are well known, but little is known about their interconnections. We tested the feasibility of using physiophysiological interaction to explore the effective connections of the network and to seek disease-related differences in connectivity. This was a secondary analysis of fMRI(More)
  • Nathan Belsher, Jin Schinnerer, Steve Brauns, Craig Spooner, Dagmar Epsten, Janet Norris +19 others
  • 2012
SUMMARY AGENDA ITEM DISCUSSION ACTION ITEMS 1 – Introductions / Attendance Attendees were introduced. N/A 2 – Review and Approval of Agenda All agenda items were approved. N/A 3 – Approval of Previous Meeting Minutes The previous meeting's minutes were approved by all members. N/A 4 – Status of Action Items from Previous Meeting. (See Attachment #2) The(More)
AIMS To identify, in subjects with overactive bladder (OAB), differences in brain activity between those who maintained and those who lost bladder control during functional magnetic resonance imaging (fMRI) of the brain with simultaneous urodynamics. METHODS Secondary analysis of a cohort of older women (aged >60) with proven urgency urinary incontinence,(More)
AIMS To determine normative data for lower urinary tract function in asymptomatic continent women without detrusor overactivity (DO) across the age span. METHODS Healthy female volunteers aged > or =20 years were recruited from the community. Comprehensive assessment included bladder diary, physical examination, uroflowmetry, and video-urodynamics.(More)