Werner Schütz

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Adenosine exerts a mitogenic effect on human endothelial cells via stimulation of the A2A-adenosine receptor. This effect can also be elicited by the beta2-adrenergic receptor but is not mimicked by elevation of intracellular cAMP levels. In the present work, we report that stimulation of the A2A-adenosine receptor and of the beta2-adrenergic receptor(More)
Multi-version software systems achieve fault tolerance through somare redundancy and diversity. In order to investigate this approach, this joint UCLAIHoneywell research project investigated multi-version sojhvare systems, employing six different programming languages to create six versions of s o p a r e for an automatic landing program. The rationale,(More)
This paper presents a systematic methodology for the design of distributed fault tolerant real-time systems. The methodology covers the stepwise reenement of the given requirements, expressed in the form of real-time transactions, to task and protocol executions. It also includes a timing analysis and dependability evaluation of the still incomplete design.(More)
The systematic development of fault-tolerant real-time systems with guaranteed timeliness requires an appropriate system architecture and a rigorous design methodology. The rst part of this paper describes those services of the architecture that help to simplify the work of the real-time programmer, taking MARS as an example. The second part deals with(More)
The systematic development of fault-tolerant real-time systems with guaranteed timeliness requires an appropriate system architecture and a rigorous design methodology. We propose a system with strict separation of the issues of synchronization, dependability aspects and data transformation. Dependability aspects (error handling and redundancy management)(More)
BACKGROUND In peripheral airways, acetylcholine induces contraction via activation of muscarinic M2-and M3-receptor subtypes (M2R and M3R). Cholinergic hypersensitivity is associated with chronic obstructive pulmonary disease and asthma, and therefore the identification of muscarinic signaling pathways are of great therapeutic interest. A pathway that has(More)
Dopamine-stimulated adenylyl cyclase activity was measured in striatal homogenates of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated rhesus monkeys and humans with idiopathic Parkinson's disease and compared with the activity in control tissue. No differences between parkinsonian and control tissue were found in the presence of 20 mM NaCl.(More)