Werner O Richter

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Familial hypercholesterolemia is a disorder of lipid metabolism associated with a highly increased risk for cardiovascular disease. Since in such patients even combined drug therapy often fails to decrease low-density lipoprotein (LDL) cholesterol levels sufficiently, extracorporeal LDL elimination has been developed. We treated eight adult patients with(More)
Because fatty acid composition of biliary phospholipids influences cholesterol secretion into bile, we investigated whether replacement of n-1 monounsaturated or n-6 polyunsaturated fatty acids with n-3 polyunsaturated fatty acids in biliary phosphatidylcholines reduces supersaturation with cholesterol and prevents precipitation of cholesterol crystals in(More)
Oxidation of low-density lipoprotein (LDL) plays a major role in the development of atherosclerosis. Hypercholesterolemia has been associated with enhanced in vitro oxidation of LDL, and lipid-lowering therapy reduces LDL oxidizability. In the present study, we investigated whether LDL apheresis performed with different techniques affects in vitro diene(More)
BACKGROUND Hyperlipidaemia associated with antiretroviral treatment has led to concerns for an increased cardiovascular risk in HIV-infected patients. OBJECTIVE To assess this cardiovascular risk by comparing the lipoprotein pattern of antiretroviral-treated and untreated HIV-positive patients with patients with familial combined hyperlipidaemia (high(More)
OBJECTIVE To study the relation between serum lipoprotein levels and the frequency of colorectal adenomas, the benign precursors of colorectal cancer. DESIGN Cross-sectional. SETTING University hospital in Germany. PATIENTS The study included 822 of 1124 consecutive patients who underwent colonoscopy at our institution (302 patients were excluded(More)
Android obesity is reported to be a risk factor for coronary heart disease and aberrations in lipid metabolism, but so far its association with other risk factors such as age and overweight has not been clearly analyzed. We therefore investigated the relationship between the waist-to-hip ratio, age, body mass index and serum lipoproteins in 305 probands(More)
beta-endorphin stimulates lipolysis in vitro in isolated fat cells of the rabbit. To exclude effects of collagenases and local proteases we investigated the effect of beta-endorphin on glycerol, free fatty acids and glucose plasma levels in the rabbit with and without naloxone. beta-endorphin increased free fatty acids and glycerol while glucose remained(More)
To verify the benofit of nonglucose carbohydrates and fiber in enteral formula diets we studied the postprandial metabolism of eight healthy subjects after the intake of two helpings (25 g carbohydrates each) of five commonly used enteral formulas over 4 h. There were no significant differences in postprandial concentrations of blood glucose among the(More)
Primary familial forms of chylomicronemia can lead to acute life-threatening complications, especially acute pancreatitis. The main aim of therapy is to avoid this so-called chylomicronemia syndrome. In 12 patients with primary chylomicronemia due to familial hypertriglyceridemia, the addition of 2.16 g omega-3 fatty acids over 4 weeks and 4.32 g for 8(More)
beta-Endorphin stimulates glycerol release from adipose tissue in vitro in the rabbit. Thirty different amino acid sequences of this peptide were tested for lipolytic activity. Four turned out to be active: porcine and human beta-endorphin-(1-31), human beta-endorphin-(6-31), and human beta-endorphin-(1-5)-(16-31). Structure-activity investigations showed(More)