Werner Fischer

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We have recently shown that highly purified lipoteichoic acid (LTA) represents a major immunostimulatory principle of Staphylococcus aureus. In order to test whether this translates to other bacterial species, we extracted and purified LTA from 12 laboratory-grown species. All LTA induced the release of TNF-alpha, IL-1beta, IL-6 and IL-10 in human whole(More)
Lipoteichoic acids (LTAs), glycolipids and, less wide-spread, teichoic acids (TAs) are characteristic components of the cell wall-membrane complex in a large group of gram-positive bacteria (for references see [ 17, 18]). After a period of hypotheses for essential functions [46], LTA and TA were for a while considered as more or less secondary cellular(More)
A detailed mathematical proof is given that the energy spectrum of a quantum particle in multi-dimensional Euclidean space under the influence of certain random potentials is pure point at sufficiently low energies. The results apply in particular to an important class of Gaussian random potentials, which are homogeneous with respect to Euclidean(More)
Virtualization techniques are getting more and more popular. They allow to run multiple virtual servers on a single physical machine. But in case of a hardware outage, tens of virtual servers are down. This paper gives some insight how to prevent this situation. “Problems of virtualization” discusses why it is necessary to think about clustering in(More)
DIETRICH MACK,* WERNER FISCHER, ANDREAS KROKOTSCH, KLAUS LEOPOLD, RUDOLF HARTMANN, HEINZ EGGE, AND RAINER LAUFS Institut für Medizinische Mikrobiologie und Immunologie, Universitätskrankenhaus Eppendorf, D-20246 Hamburg, Institut für Biochemie der Medizinischen Fakultät, Universität Erlangen-Nürnberg, D-91054 Erlangen, and Institut für Physiologische(More)
A complex polydispersity became apparent when the poly(glycerophosphate) lipoteichoic acid of Enterococcus faecalis was chromatographed on DEAE-sephadex. The chain length varied between 13 and 33 glycerophosphate residues per lipid anchor. In parallel, the extent of chain glycosylation increased from 0.2 to 0.4 diglucosyl residues per glycerophosphate unit.(More)
For some types of sphere packing with typical one- and two-dimensional parameter regions, the sphere-packing density as a function of the free parameters is discussed. In addition, some sphere-packing types with extraordinary density properties are presented. Until now, it was generally assumed that sphere packings with minimal density are also those of(More)
Load commutated inverters (LCI) cover a large variety of industry applications in a power range up to 100 MW. The paper discusses realized applications in power generation, oil and gas, marine drives, and metal industry. A new LCI family with a high grade of modularity allows covering all these applications with a minimum of different parts. The heart of(More)
All homogeneous sphere packings with triclinic symmetry have been derived by studying the characteristic Wyckoff positions P -1 1a and P -1 2i of the two triclinic lattice complexes. These sphere packings belong to 30 different types. Only one type exists that has exclusively triclinic sphere packings and no higher-symmetry ones. The inherent symmetry of(More)