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Quantitative analyses were carried out on a large number of proteins that contain the highly conserved basic helix-loop-helix domain. Measures derived from information theory were used to examine the extent of conservation at amino acid sites within the bHLH domain as well as the extent of mutual information among sites within the domain. Using the(More)
An information theoretic approach is used to examine the magnitude and origin of associations among amino acid sites in the basic helix-loop-helix (bHLH) family of transcription factors. Entropy and mutual information values are used to summarize the variability and covariability of amino acids comprising the bHLH domain for 242 sequences. When these(More)
T-theory is the name that we adopt for the theory of trees , injective envelopes of metric spaces , and all of the areas that are connected with these topics , which has been developed over the past 10 – 15 years in Bielefeld. Its motivation was originally—and still is to a large extent—the development of mathematical tools for reconstructing phylogenetic(More)
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