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Adult female Swiss-Webster and B6C3F1 mice received distilled water only or water containing 0.1, 1.0, 10, 100, or 1000 ppb of aldicarb daily for 34 days. The target concentration of aldicarb present in the 10 ppb dosing solution was analytically verified on a daily basis as was its stability over a 48-hr period. To develop an immune profile of this… (More)
Exposure of hamster tracheal organ cultures to gas phase singlet delta oxygen, O2, at atmospheric pressure produced significant alterations in the mucociliary epithelium resulting in changes in ciliary activity and cellular morphology.
Autoradiographic identification of unscheduled DNA synthesis (UDS) in short-term organ culture of hamster tracheal epithelium has been used as a predictive test for mutagenic and/or carcinogenic compounds. Tracheal explants were treated for 2 h with singlet delta oxygen plus [3H]thymidine. Silver grains over the nuclei of epithelial cells from the… (More)
The toxic effects of gas-phase singlet oxygen, 1O2, on the ciliated respiratory epithelium of hamster trachea have been demonstrated. Tracheal explants treated with 1O2 showed a dose-dependent decrease in cilia beating frequency and focal ciliostasis. A statistically significant decrease in ciliary activity occurred at 1O2 concentrations as low as 154 ppb… (More)
Singlet delta oxygen (1O2) was generated at atmospheric pressure using heterogeneous gas-phase photosensitization. Polycyclic aromatic hydrocarbons (PAH), known constituents of the atmosphere, were found to be efficient sensitizers in the production of singlet delta oxygen under simulated environmental conditions. A novel mechanism involving singlet delta… (More)
Singlet-oxygen (1O2) was generated in the gas phase by heterogeneous photosensitization and bubbled into suspensions of phosphatidylcholine (PC) liposomes. Lipid peroxidation and membrane lysis were observed, and were dependent on the 1O2 concentration and the degree of unsaturation of the liposome. An analysis based on large target diffusion theory… (More)
Singlet oxygen was generated in the gas phase at atmospheric pressure by the method of heterogeneous photosensitization. In vitro exposure of human lung WI-38 fibroblasts to gas-phase singlet oxygen resulted in sister chromatid exchange.