Wenzhu Zhang

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The beta-site APP cleaving enzyme-1 (BACE1) mediates the first cleavage of the beta-amyloid precursor protein (APP) to yield the amyloid beta-peptide (Abeta), a key pathogenic agent in Alzheimer's disease (AD). Using a proteomic approach based on in-cell chemical cross-linking and tandem affinity purification (TAP), we herein identify sorting nexin 6 (SNX6)(More)
Energy harvesting sensor nodes based on real nonvolatile processors are demonstrated to show the desirable characteristics of those systems, such as no battery, zero stand-by power, microsecond-scale sleep and wake-up time, high resilience to random power failures and fine-grained power management. Furthermore, we show its applications to a distributed(More)
Hyperglycemia, as well as diabetes mellitus, has been shown to impair ATP-sensitive K+ (KATP) channels in human vascular smooth muscle cells. Hydrogen sulfide (H2S) is also known to be an opener of KATP channels. We previously demonstrated the cardioprotective effects exerted by H2S against high-glucose (HG, 35 mM glucose)-induced injury in H9c2 cardiac(More)
During the vast trend of urbanization, mobile sensing in metropolitan area has become an emerging fashion and prevailing technology to monitor the environmental changes and human activities in the city scale. In this paper, we propose a novel framework, namely, the Context-Aware Metropolitan Sensing (CAMS), to rise to the increasing challenges in context(More)
Modern cities, with large population and complicated infrastructures, are complex entities with non-linear and dynamic properties that challenge the city management. Therefore, as the first step towards the goal of thorough understanding of the phenomena, pervasive urban sensing have become a cornerstone of future smart city that enhance the interplay(More)
In this paper we present a Platform-as-a-Service (PaaS) approach for rapid development of wireless sensor network (WSN) applications based on the dinam-mite concept, i.e. an embedded web-based development environment and run-time platform for WSN systems integrated in a single information appliance. The PaaS is hosted by a cloud of dinam-mite nodes which(More)
This paper focuses on consumer-side activities and investigates the environmental impact of the electrical energy consumer (transportation, buildings, street lighting, etc.), in order to improve the operational efficiency of the city as a whole. To achieve the goal we propose a two-layer approach which consists of a sensing layer and an application layer.(More)
To solve collisions of topology-transparent schedules in multihop ad hoc networks, we propose a topology-transparent schedule with reservation and carrier sense. Our schedule is based on slotted architecture in which each slot is divided into reservation phase and data phase. Each node resolves possible collisions in its assigned slots by reservation and(More)