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The beta-site APP cleaving enzyme-1 (BACE1) mediates the first cleavage of the beta-amyloid precursor protein (APP) to yield the amyloid beta-peptide (Abeta), a key pathogenic agent in Alzheimer's disease (AD). Using a proteomic approach based on in-cell chemical cross-linking and tandem affinity purification (TAP), we herein identify sorting nexin 6 (SNX6)(More)
Energy harvesting sensor nodes based on real nonvolatile processors are demonstrated to show the desirable characteristics of those systems, such as no battery, zero stand-by power, microsecond-scale sleep and wake-up time, high resilience to random power failures and fine-grained power management. Furthermore, we show its applications to a distributed(More)
During the vast trend of urbanization, mobile sensing in metropolitan area has become an emerging fashion and prevailing technology to monitor the environmental changes and human activities in the city scale. In this paper, we propose a novel framework, namely, the Context-Aware Metropolitan Sensing (CAMS), to rise to the increasing challenges in context(More)
Modern cities, with large population and complicated infrastructures, are complex entities with non-linear and dynamic properties that challenge the city management. Therefore, as the first step towards the goal of thorough understanding of the phenomena, pervasive urban sensing have become a cornerstone of future smart city that enhance the interplay(More)
—This paper focuses on consumer-side activities and investigates the environmental impact of the electrical energy consumer (transportation, buildings, street lighting, etc.), in order to improve the operational efficiency of the city as a whole. To achieve the goal we propose a two-layer approach which consists of a sensing layer and an application layer.(More)
A novel CEQRP (cost-efficient QoS routing protocol) for mobile ad hoc networks (MANETs) is proposed. CEQRP can provide QoS guarantee and is aimed at extending the battery's lifetime at each host by selecting the hosts with a long battery's remaining lifetime to forward packets. Simulation results show that CEQRP has good network performance. Furthermore,(More)
This article has been accepted for publication in a future issue of this journal, but has not been fully edited. Content may change prior to final publication. Abstract—We address the link scheduling problem in wireless multi-hop networks under the realistic physical interference model. Different from most work that adopt the protocol interference model(More)
With the advancement of the sensor network technology and cyber physical systems [2], the merging between the virtual cyber space and the real physical world is bound to happen, which will impact the lifestyle of the human being. The metropolitan area sensor networks, composed of millions of heterogeneous sensors and penetrating every aspect of the city(More)