Wenyuan Yin

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China's methadone maintenance treatment program was initiated in 2004 as a small pilot project in just eight sites. It has since expanded into a nationwide program encompassing more than 680 clinics covering 27 provinces and serving some 242 000 heroin users by the end of 2009. The agencies that were tasked with the program's expansion have been confronted(More)
—The popularity of mobile devices equipped with various cameras has revolutionized modern photography. People are able to take photos and share their experiences anytime and anywhere. However, taking a high quality photograph via mobile device remains a challenge for mobile users. In this paper we investigate a photography model to assist mobile users in(More)
—This paper proposes a semantic image adaptation scheme for heterogeneous mobile display devices. This scheme aims to provide mobile users with the most desired image content by integrating the content semantic importance with user preferences under limited mobile display constraints. The main contributions of the proposed scheme are: 1) seamless(More)
Automatic photo quality assessment emerged as a hot topic in recent years for its potential in numerous applications. Most existing approaches to photo quality assessment have predominantly focused on image content itself, while ignoring various contexts such as the associated geo-location and timestamp. However, such a universal aesthetic assessment model(More)
OBJECTIVE To assess the overall mortality of methadone maintenance treatment (MMT) clients in China and its associated factors. METHODS A total of 1,511 MMT clients, all of whom enrolled in China's first eight MMT clinics between March and December 2004, were included in this cohort study and followed for approximately six years, until June 2010.(More)
The present study tested the hypothesis that GABA(A) and opioid receptors within the central nucleus of the amygdala (CeA) regulate ethanol (EtOH), but not sucrose-maintained responding. To accomplish this, betaCCt, a mixed benzodiazepine (BDZ) agonist-antagonist with binding selectivity at the alpha1 subunit-containing GABA(A) receptor, and the(More)
It has been hypothesized that alcohol addiction is mediated, at least in part, by specific gamma-aminobutyric acid(A) (GABA(A)) receptors within the ventral pallidum (VP). Among the potential GABA(A) receptor isoforms regulating alcohol-seeking behaviors within the VP, the GABA(A) alpha1 receptor subtype (GABA(A1)) appears pre-eminent. In the present study,(More)
The present study investigated the role of the alpha1-containing GABA(A) receptors in the neurobehavioral actions of alcohol. In Experiment 1, mice lacking the alpha1 subunit (alpha1 (-/-)) were tested for their capacity to initiate operant-lever press responding for alcohol or sucrose. Alcohol intake in the home cage was also measured. In Experiment 2, the(More)
Recent research on genetically modified mice has attributed the amnesic effect of benzodiazepines mainly to the alpha1-containing GABA(A) receptor subtypes. The pharmacological approach, using subtype selective ligands, is needed to complement genetic studies. We tested the effects of the non-selective antagonist flumazenil (0-20.0 mg/kg), the preferential(More)