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In the late stages of the retroviral life cycle, the transcription of viral pre-mRNA is initiated at the 5′ long terminal repeat (5′ LTR) and terminated at the 3′ LTR; the full-length and spliced viral RNAs are transported out of the nucleus and serve as templates for the translation of viral proteins or alternatively as the full-length viral genome to be(More)
The multifunctional transactivator Tat protein is an essentially regulatory protein for HIV-1 replication and it plays a role in pathogenesis of HIV-1 infection. At present, numerous experimental studies about HIV-1 Tat focus on subtype B, very few has been under study of subtype C-Tat. In view of the amino acid variation of the clade-specific Tat proteins,(More)
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