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Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib
TLDR
DMC increases intracellular free calcium levels and potently triggers the ESR in various tumor cell lines, as indicated by transient inhibition of protein synthesis, activation of ER stress–associated proteins GRP78/BiP, CHOP/GADD153, and caspase-4, and subsequent tumor cell death.
Insulin-regulated Aminopeptidase Is a Key Regulator of GLUT4 Trafficking by Controlling the Sorting of GLUT4 from Endosomes to Specialized Insulin-regulated Vesicles
TLDR
IRAP is a key regulator of GLUT4 trafficking by controlling sorting from endosomes to specialized insulin-regulated vesicles in patients with type 2 diabetes.
HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress.
TLDR
The results support a model whereby PIs cause tumor cell death via triggering of the ESR, inhibition of proteasome activity, and subsequent accumulation of misfolded proteins.
Specialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs
TLDR
RAB10 and RAB14 function at sequential steps of insulin-stimulated GLUT4 translocation to the plasma membrane, and R AB10 and its GAP protein comprise the main signaling module that regulates the accumulation of GLut4 transport vesicles at the plasma membranes.
GLUT4 Is Sorted to Vesicles Whose Accumulation Beneath and Insertion into the Plasma Membrane Are Differentially Regulated by Insulin and Selectively Affected by Insulin Resistance
GLUT4 is sorted to vesicles whose accumulation beneath and insertion into the plasma membrane are differentially regulated by insulin and selectively affected by insulin resistance.
Human Insulin Vesicle Dynamics During Pulsatile Secretion
TLDR
Using expressed fluorescent vesicle cargo proteins and total internal reflection fluorescence (TIRF) microscopy, it is demonstrated that glucose stimulates human pancreatic β-cells to secrete insulin vesicles in short, coordinated bursts of ∼70 vesicular cargo proteins each.
Mechanisms of peptide hormone secretion
Super-resolution microscopy reveals the insulin-resistance-regulated reorganization of GLUT4 on plasma membranes
TLDR
The organization of membrane-fused GLUT4 is regulated by insulin and insulin resistance, and the F5QQI motif and lipid rafts are proven to be associated with the maintenance ofGLUT4 clusters on the plasma membrane.
Variation in Carbohydrates between Cancer and Normal Cell Membranes Revealed by Super‐Resolution Fluorescence Imaging
TLDR
Findings on the aberrant distributions of cancer‐associated carbohydrates can potentially serve as novel diagnostic and therapeutic targets, as well as making a contribution to clarify how abnormal glycosylations of membrane glycoconjugates participate in tumorigenesis and metastasis.
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