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SAMHD1 is a dGTP-activated deoxynucleoside triphosphate triphosphohydrolase (dNTPase) whose dNTPase activity has been linked to HIV/SIV restriction. The mechanism of its dGTP-activated dNTPase function remains unclear. Recent data also indicate that SAMHD1 regulates retrotransposition of LINE-1 elements. Here we report the 1.8-Å crystal structure of(More)
The lentiviral accessory proteins Vpx and Vpr are known to utilize CRL4 (DCAF1) E3 ligase to induce the degradation of the host restriction factor SAMHD1 or host helicase transcription factor (HLTF), respectively. Selective disruption of viral CRL4 (DCAF1) E3 ligase could be a promising antiviral strategy. Recently, we have determined that posttranslational(More)
This study aims at developing a multivariate pattern analysis (MVPA) approach for making accurate predictions about antidepressant medication status of major depressive individuals based on resting-state functional connectivity magnetic resonance imaging (rs-fcMRI) data. The experimental results showed that, by training the linear support vector machine(More)
  • Wenying Gao
  • 2006 CIE International Conference on Radar
  • 2006
The overall high performance requirements for the modern radar system set higher and higher requirements for the radar frequency source, such as high spectrum purity, low phase noise and wide bandwidth, fast frequency switching speed, and complex signal generation capability, etc. and drive continuously the development of radar frequency source technique.(More)
The dehydrogenation of benzene on Pt(111) surface is studied by ab initio density functional theory. The minimum energy pathways for benzene dehydrogenation are found with the nudge elastic band method including several factors of the associated barriers, reactive energies, intermediates, and transient states. The results show that there are two possible(More)
The virion infectivity factor (Vif) open reading frame is conserved among most lentiviruses. Vif molecules contribute to viral replication by inactivating host antiviral factors, the APOBEC3 cytidine deaminases. However, various species of lentiviral Vif proteins have evolved different strategies for overcoming host APOBEC3. Whether different species of(More)
The effect of androsterol, whose structure resembles that of cholesterol but without the alkyl side chain, on the phase behavior of aqueous dispersions of dipalmitoylphosphatidylcholine has been studied to understand the role of the side chain played in the formation of ordered phases of the type observed in membrane rafts. Thermotropic changes in the(More)
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