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TRPM2 is a Ca(2+)-permeable channel that is activated by oxidative stress and confers susceptibility to cell death. Here, an isoform of TRPM2 was identified in normal human bone marrow that consists of the TRPM2 N terminus and the first two predicted transmembrane domains. Because of alternative splicing, a stop codon (TAG) is located at the splice junction(More)
The FCC recently issued the regulatory rules for cognitive radio use of the TV white space spectrum. These new rules provide an opportunity but they also introduce a number of technical challenges. The challenges require development of cognitive radio technologies like spectrum sensing as well as new wireless PHY and MAC layer designs. These challenges(More)
This paper proposes a two microphone-based source localization technique for multiple speech sources utilizing speech specific properties and novel clustering algorithms. Voiced speech is sparse in the frequency domain and can be represented by sinusoidal tracks via sinusoidal modeling which provides high local signal-to-noise ratio (SNR). By utilizing the(More)
In this paper, frequency-domain relay processing in a two-hop transmission system is investigated. The relay is constrained to be “non-regenerative”; that is, the relay is only allowed to perform symbolby-symbol memoryless transformation of its received signals. Multicarrier modulation, e.g., orthogonal frequency division multiplexing (OFDM), is utilized to(More)
TRPM2 is a Ca(2+)-permeable channel activated by oxidative stress or TNF-alpha, and TRPM2 activation confers susceptibility to cell death. The mechanisms were examined here in human monocytic U937-ecoR cells. This cell line expresses full-length TRPM2 (TRPM2-L) and several isoforms including a short splice variant lacking the Ca(2+)-permeable pore region(More)
TRPM2, a member of the transient receptor potential (TRP) superfamily, is a Ca(2+)-permeable channel, which mediates susceptibility to cell death following activation by oxidative stress, TNFalpha, or beta-amyloid peptide. We determined that TRPM2 is rapidly tyrosine phosphorylated after stimulation with H(2)O(2) or TNFalpha. Inhibition of tyrosine(More)
TRPM2, a member of the transient receptor potential (TRP) superfamily, is a Ca(2+)-permeable channel activated by oxidative stress or tumor necrosis factoralpha involved in susceptibility to cell death. TRPM2 activation is dependent on the level of intracellular Ca(2+). We explored whether calmodulin (CaM) is the Ca(2+) sensor for TRPM2. HEK 293T cells were(More)
Motivated by the demand for energy-efficient communication solutions in the next generation cellular network, a mixed receiver architecture for massive multiple input multiple output (MIMO) systems is proposed, which differs from previous works in that herein one-bit analog-to-digital converters (ADCs) partially replace the conventionally assumed(More)
Suppose that a rumor originating from a single source among a set of suspects spreads in a network, how to root out this rumor source? With the a priori knowledge of suspect nodes and a snapshot observation of infected nodes, we construct a maximum a posteriori (MAP) estimator to identify the rumor source using the susceptible-infected (SI) model. We(More)