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Value of micro-proteinuria in combination with ultrasonography of the left renal vein in the diagnosis of orthostatic proteinuria.
TLDR
The combination of ultrasonography of the LRV and elevated micro-proteinuria after activity could achieve the Se, Sp, PPV, NPV, PLR (weighted by prevalence, W), NLR (W) and YI at 93.3% in the diagnosis of OP.
A single-center analysis of Henoch-Schonlein purpura nephritis with nephrotic proteinuria in children
TLDR
The serum albumin and IgG levels of the NP group were significantly lower; however, their blood urea nitrogen and cystatin C levels were higher and the ISKDC grades were mainly above grade III.
Compositional alterations of gut microbiota in children with primary nephrotic syndrome after initial therapy
TLDR
Initial therapy of PNS increased SCFA-producing gut microbiota, but might diminish selenocompound metabolism, isoflavonoid biosynthesis and phosphatidylinositol signaling system in children.
A novel missense mutation of COL4A5 gene alter collagen IV α5 chain to cause X-linked Alport syndrome in a Chinese family.
TLDR
The results of real-time PCR, western blot and immunofluorescence showed that in the mutation group, both the mRNA and protein levels of COL4A5 were significantly reduced, which might play a very important role in the occurrence and development of AS.
P53 inhibitor pifithrin-α prevents the renal tubular epithelial cells against injury.
TLDR
It is shown that pifithrin-α can facilitate the progression of renal tubular epithelial cells through G2/M phase, protecting them against injury.
Follow-up results of children with melamine induced urolithiasis: a prospective observational cohort study
TLDR
Early passage of a stone may reduce the renal injury induced by melamine-contaminated milk powder-associated urolithiasis, and the size of the stone was correlated with the duration of exposure to melamine.
254C>G: a TRPC6 promoter variation associated with enhanced transcription and steroid-resistant nephrotic syndrome in Chinese children
TLDR
254C>G, a SNP underlying enhanced TRPC6 transcription and expression, may be correlated with the development of steroid resistance in Chinese children with idiopathic nephrotic syndrome.
[Comparison of cyclophosphamide and cyclosporine in the treatment of steroid-resistant idiopathic nephrotic syndrome in children].
TLDR
For children with MCD, CsA combining prednisolone could result in a higher remission rate than intravenous CTX combining predisonsolone, according to a retrospective study analysed in a retrospective Study of steroid-resistant idiopathic nephrotic syndrome in children.
The expression of response gene to complement 32 on renal ischemia reperfusion injury in rat
TLDR
RGC32 may play an important role in the pathogenesis of AKI following IRI and repair in rat and the in vitro experiments show the expression of α-SMA and extracellular matrix expression increased signification when the RGC32 was silenced.
[Long-term effects of cyclosporine A in children with steroid-resistant idiopathic nephrotic syndrome and outcomes of the patients].
TLDR
CsA treatment was confirmed to be effective in children with steroid-resistant idiopathic nephrotic syndrome and Renal fibrosis was rare in patients treated with a low dose of CsA for 2 years.
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