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Whole-genome amplification (WGA) for next-generation sequencing has seen wide applications in biology and medicine when characterization of the genome of a single cell is required. High uniformity and fidelity of WGA is needed to accurately determine genomic variations, such as copy number variations (CNVs) and single-nucleotide variations (SNVs).(More)
A large number of data need to be transmitted in high-speed between Field Programmable Gate Array (FPGA) and Advanced RISC Machines 11 micro-controller (ARM11) when we design a small data acquisition (DAQ) system for nuclear experiments. However, it is a complex problem to beat the target. In this paper, we will introduce a method which can realize the(More)
Fluorogenic sequencing is a sequencing-by-synthesis technology that combines the advantages of pyrosequencing and fluorescence detection. With native duplex DNA as the major product, we employ polymerase to incorporate the complement- arily matched terminal phosphate-labeled fluorogenic nucleotides into the DNA template and release halogen-fluorescein as(More)
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