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A Novel Two-Component Signaling System Facilitates Uropathogenic Escherichia coli's Ability to Exploit Abundant Host Metabolites
TLDR
This study describes the first UPEC-associated TCS that functions in controlling the utilization of α-ketoglutarate in vivo thereby facilitating UPEC adaptation to life inside the urinary tract. Expand
FNR Regulates Expression of Important Virulence Factors Contributing to Pathogenicity of Uropathogenic Escherichia coli
TLDR
FNR regulates motility and multiple virulence factors, including expression of type I and P fimbriae, modulation of hemolysin expression, and expression of a novel pathogenicity island involved in α-ketoglutarate metabolism under anaerobic conditions. Expand
Transcriptome Analysis of Avian Pathogenic Escherichia coli O1 in Chicken Serum Reveals Adaptive Responses to Systemic Infection
TLDR
This genome-wide analysis provides novel insight into processes that are important to the pathogenesis of APEC O1, and includes several known virulence genes and genes involved in adaptive metabolism, protein transport, biosynthesis pathways, stress resistance, and virulence regulation. Expand
Host legume‐exuded antimetabolites optimize the symbiotic rhizosphere
TLDR
It is suggested that host legumes may exude specific antimetabolites into their surroundings to optimize the bacterial population in order to have successful symbiotic events with rhizobia. Expand
Proteome response of an extraintestinal pathogenic Escherichia coli strain with zoonotic potential to human and chicken sera.
TLDR
The proteomic response of an avian pathogenic E. coli strain was compared following growth in human and avian sera to determine whether it uses the same mechanisms to overcome the antibacterial effects of sera from different host species. Expand
A novel small RNA Bmsr1 enhances virulence in Brucella melitensis M28.
TLDR
The contribution of a novel sRNA Bmsr1 to virulence of B. melitensis M28 is revealed, probably by influencing genes involved in T4SS, virulence regulator VjbR and other metabolism genes. Expand
Transcriptional Control of Dual Transporters Involved in α-Ketoglutarate Utilization Reveals Their Distinct Roles in Uropathogenic Escherichia coli
TLDR
The authors' phylogenetic analyses support that kgtP is a widely conserved locus in commensal and pathogenic E. coli, while UPEC-associated c5038 was acquired through horizontal gene transfer, and different transcriptional regulation led to distinct roles played by C5038 and KgtP in KG utilization and fitness in vivo. Expand
The Twin-Arginine Translocation System Is Important for Stress Resistance and Virulence of Brucella melitensis
TLDR
It is demonstrated that Tat is required for full virulence of B. melitensis M28 and Genome-wide in silico prediction combined with in vivo amidase reporter assay indicates that at least 23 proteins are authentic Tat substrates, and they are functionally categorized into solute-binding proteins, oxidoreductases, cell envelope biosynthesis enzymes, and others. Expand
Murine SIGNR1 (CD209b) Contributes to the Clearance of Uropathogenic Escherichia coli During Urinary Tract Infections
TLDR
The results of this study indicate that the innate immune receptor CD209s participate in the clearance of UPEC during UTIs, and mice lacking SIGNR1 are more susceptible to infection of this uropathogen, leading to prolonged bacterial persistence. Expand
Whole genome sequencing analysis of avian pathogenic Escherichia coli from China.
TLDR
The phylogenetic analysis indicated a great diversity of APEC isolates, and a total of 35 different O types, 22 H types, and 29 ST types were identified, and several virulence-associated genes, which have been reported in other E. coli pathotypes but have not be reported in APEC, were identified in this study. Expand
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