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Notch signaling in the nervous system is often regarded as a developmental pathway. However, recent studies have suggested that Notch is associated with neuronal discharges. Here, focusing on temporal lobe epilepsy, we found that Notch signaling was activated in the kainic acid (KA)-induced epilepsy model and in human epileptogenic tissues. Using an acute(More)
Existing Byzantine fault tolerant (BFT) storage solutions that achieve strong consistency and high availability, are costly compared to solutions that tolerate simple crashes. This cost is one of the main obstacles in deploying BFT storage in practice. In this paper, we present PoWerStore, a robust and efficient data storage protocol. PoWerStore's(More)
AIM Some gradient of Huisheng oral solution (HOS) has been reported to have anti-fibrosis activity. This study was designed to investigate whether HOS could inhibit liver fibrosis and to elucidate its molecular mechanism of action. MATERIALS AND METHODS Hepatic fibrosis model in rat was induced by subcutaneous injection of CCl4. Rats in the treatment(More)
Acute liver failure (ALF) is characterized by impaired regeneration of hepatocytes, partially resulting from the defective signaling between elevated levels of hepatocyte growth factor (HGF) and the downregulation of its receptor, c-met. In this study, we assess the therapeutic efficacy of in vivo c-met gene transfer in ALF. We established a(More)
Superresolution fluorescence microscopy is used to locate single copies of RNA polymerase (RNAP) in live Escherichia coli and track their diffusive motion. On a timescale of 0.1-1 s, most copies separate remarkably cleanly into two diffusive states. The "slow" RNAPs, which move indistinguishably from DNA loci, are assigned to specifically bound copies (with(More)
OBJECTIVE To determine the microRNA (miRNA) expression signature and its clinical significance in endometrioid carcinoma (EC). METHODS The miRNA profiles were analyzed by miRNA microarray in 73 cases of EC. The expression level of the eight selected miRNAs were measured by real-time fluorescent quatitative PCR(qRT-PCR). Immunohistochemistry (IHC) was(More)
Bring Your Own Device (BYOD) is attracting considerable attention nowadays. In BYOD scenarios, enterprises wish to integrate their employees’ mobile devices in enterprise operations (e.g., reading emails, editing documents). This clearly raises serious security concerns since the mobile device in question is not under the control of the enterprise and is(More)
During the last decade, increasing evidence suggested that bone marrow stromal cells (MSCs) have the potential to differentiate into neural lineages. Many studies have reported that MSCs showed morphological changes and expressed a limited number of neural proteins under experimental conditions. However, no proteomic studies on MSCs differentiated into(More)
In Erwinia amylovora, ECF (extracytoplasmic functions) alternative sigma factor HrpL regulates the transcription of hrp (hypersensitive response and pathogenicity)-type III secretion system (T3SS) genes by binding to a consensus sequence known as the hrp box in hrp gene promoters. In turn, the expression of hrpL has been proposed to be positively controlled(More)