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We have investigated human male demographic history using 590 males from 51 populations in the Human Genome Diversity Project - Centre d'Etude du Polymorphisme Humain worldwide panel, typed with 37 Y-chromosomal Single Nucleotide Polymorphisms and 65 Y-chromosomal Short Tandem Repeats and analyzed with the program Bayesian Analysis of Trees With Internal(More)
The HLA system is the most polymorphic of all human genetic systems. The frequency of HLA class I alleles and their linkage disequilibrium patterns differ significantly among human populations as shown in studies using serologic methods. Many DNA-defined alleles with identical serotypes may have variable frequencies in different populations. We typed HLA-A,(More)
To study associations between type 2 diabetes (T2DM) candidate genes and microvascular complications of diabetes (MVCDs), we performed case-control association studies for both T2DM and MVCDs in Han Chinese subjects. We recruited 1,939 unrelated Han Chinese T2DM patients and 918 individuals with normal blood glucose levels as nondiabetic controls. Among(More)
We constructed a highly responsive ascorbic acid (AA) sensor utilizing over-oxidized polypyrrole (OPPy) and Palladium nanoparticles (PdNPs) composites (OPPy-PdNPs). In the presence of PdNPs, polypyrrole (PPy) was coated on a gold (Au) electrode through cyclic voltammetry (CV) and over-oxidized at a fixed potential in NaOH solution. The PdNPs were(More)
A label-free immunosensor was developed to detect the presence of an antigen. This immunosensor was based on the modulation of the electrochemistry of the surface bound redox species K(3)Fe(CN)(6) (FC). The model antigen was carcinoembryonic antigen (CEA) and the model epitope was the antibody of CEA (anti-CEA). Glassy carbon (GC) electrode surfaces were(More)
Dopa-responsive dystonia (DRD) is a rare inherited dystonia that responds very well to levodopa treatment. Genetic mutations of GTP cyclohydrolase I (GCH1) or tyrosine hydroxylase (TH) are disease-causing mutations in DRD. To evaluate the genotype-phenotype correlations and diagnostic values of GCH1 and TH mutation screening in DRD patients, we carried out(More)
In this paper, we propose a robust sparse spectrum fitting method (RSpSF) for Directions-Of-Arrival (DOA) and power estimation in the presence of general form of modeling errors in the array manifold matrix. By exploiting the group sparsity between the power spectrum and the modeling errors, RSpSF formulates the estimator as a convex optimization program.(More)
We report on the utilization of triangular silver nanoprisms (AgTNPs) to create a highly responsive glucose biosensor. Glucose oxidase (GOD) was simply mixed with AgTNPs and cross-linked on the Pt electrode with chitosan (CHIT) medium by glutaraldehyde. Circular dichroism (CD) and UV-spectrum results show that the activity of GOD was preserved after(More)
The mammalian central nervous system (CNS) relies on a constant supply of external glucose for its undisturbed operation. This article presents an implantable Multi-Electrode Array (MEA) probe for brain glucose measurement. The MEA was implemented on Silicon-On-Insulator (SOI) wafer using Micro-Electro-Mechanical-Systems (MEMS) methods. There were 16(More)
—Maximum Likelihood estimator (ML) has shown excellent performance of Direction Of Arrival (DOA) estimation in Multiple Input Multiple Output (MIMO) array. However, the computation burden of MIMO ML is very large. In order to resolve this problem, a novel MIMO Maximum Likelihood DOA Estimation based on Metropolis-Hasting Sampling (MIMO MHML) is proposed,(More)