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A mathematical model describing the thermomechanical interactions in biological bodies at high temperature is proposed by treating the soft tissue in biological bodies as a thermoporoelas-tic media. The heat transfer and elastic deformation in soft tissues are examined based on the Pennes bioheat transfer equation and the modified Duhamel-Neuman equations.(More)
A novel convection-diffusion-reaction model is developed to simulate fibroblast growth factor (FGF-2) binding to cell surface receptors (FGFRs) and heparan sulfate proteoglycans (HSPGs) under flow conditions within a cylindrical-shaped vessel or capillary. The model consists of a set of coupled nonlinear partial differential equations (PDEs) and a set of(More)
This paper presents a numerical solution to describe growth factor-receptor binding under flow through hollow fibers of a bioreactor. The multi-physics of fluid flow, the kinetics of fibroblast growth factor (FGF-2) binding to its receptor (FGFR) and heparan sulfate proteoglycan (HSPG) and FGF-2 mass transport is modeled by a set of coupled nonlinear(More)
This paper describes the application of Newton's method to low Mach number steady and unsteady laminar diffusion flames, which are characterized by low flow speed and highly variable density. The newly-emerged vorticity-velocity formulation of the Navier-Stokes equations is used for both steady and unsteady compressible flows to avoid staggered mesh(More)
—This paper describes a multigrid finite volume method developed to speed up the solution process for simulating complex biological transport phenomena. The method is applied to a model system which includes flow through a cell-lined cylindrical vessel and includes fibroblast growth factor-2 (FGF-2) within the fluid capable of binding to receptors and(More)
A binary spike-time-dependent plasticity (STDP) protocol based on one resistive-switching random access memory (RRAM) device was proposed and experimentally demonstrated in the fabricated RRAM array. Based on the STDP protocol, a novel unsupervised online pattern recognition system including RRAM synapses and CMOS neurons is developed. Our simulations show(More)
A three-dimensional (3D) multilayer model based on the skin physical structure is developed to investigate the transient thermal response of human skin subject to laser heating. The temperature distribution of the skin is modeled by the bioheat transfer equation, and the influence of laser heating is expressed as a source term where the strength of the(More)