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Control of brown and beige fat development
Brown and beige adipocytes expend chemical energy to produce heat and are therefore important in regulating body temperature and body weight. Brown adipocytes develop in discrete and relativelyExpand
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Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.
Prdm16 is a transcription factor that regulates the thermogenic gene program in brown and beige adipocytes. However, whether Prdm16 is required for the development or physiological function of brownExpand
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Ebf2 is a selective marker of brown and beige adipogenic precursor cells
Significance High levels of brown/beige fat activity protects animals against metabolic disease, but there has been little known about the precursor cells that mediate the expansion of brown or beigeExpand
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Cidea promotes hepatic steatosis by sensing dietary fatty acids
High levels of dietary saturated fat have been closely associated with the development of hepatic steatosis, but the factors that mediate this process remain elusive. Here, we observed that the levelExpand
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Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids
Adequate lipid secretion by mammary glands during lactation is essential for the survival of mammalian offspring. However, the mechanism governing this process is poorly understood. Here we show thatExpand
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A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate.
The precursor cells for metabolically beneficial beige adipocytes can alternatively become fibrogenic and contribute to adipose fibrosis. We found that cold exposure or β3-adrenergic agonistExpand
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Single‐cell transcriptomics and functional target validation of brown adipocytes show their complex roles in metabolic homeostasis
Brown adipocytes (BAs) are specialized for adaptive thermogenesis and, upon sympathetic stimulation, activate mitochondrial uncoupling protein (UCP)‐1 and oxidize fatty acids to generate heat. TheExpand
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miR‐20a inhibits hypoxia‐induced autophagy by targeting ATG5/FIP200 in colorectal cancer
Autophagy is a highly conserved lysosome‐mediated protective cellular process in which cytosolic components, including damaged organelles and long‐lived proteins, are cleared. Many studies have shownExpand
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