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Journals and Conferences
We have rationally constructed a novel FRET-based ratiometric thiol probe suitable for ratiometric imaging in living cells based on the native chemical ligation reaction.
Near-infrared (NIR) fluorescent sensors have emerged as promising molecular tools for imaging biomolecules in living systems. However, NIR fluorescent sensors are very challenging to be developed. Herein, we describe the discovery of a new class of NIR fluorescent dyes represented by 1a/1c/1e, which are superior to the traditional 7-hydroxycoumarin and… (More)
A fluorescence turn-on probe for Cu(2+) based on the novel copper-mediated dihydrorosamine oxidation reaction has been constructed and employed in the detection of Cu(2+) in water, new born calf serum, and living cells, and the new copper-mediated dihydrorosamine oxidation reaction likely proceeds by a copper redox mechanism.
We have designed and synthesized the highly selective and reversible fluorescent chemosensor 1 for Au(3+) by modifications on the fluorescent copper chemodosimeter 2, and we have further demonstrated that chemosensor 1 could be employed to image Au(3+) in living cells.