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Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus.
TLDR
Findings indicate that UC MSCT results in amelioration of disease activity, serologic changes, and stabilization of proinflammatory cytokines in patients with severe and treatment-refractory SLE.
Exosomes in cancer: small particle, big player
TLDR
The multifaceted roles of exosomes, the small secreted particles, in communicating with other cells within tumor microenvironment are reviewed, suggesting they may provide promising biomarkers for cancer diagnosis and represent new targets for cancer therapy.
Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis.
TLDR
Results suggest that hucMSC-Ex could ameliorate CCl4-induced liver fibrosis by inhibiting EMT and protecting hepatocytes, which provides a novel approach for the treatment of fibrotic liver disease.
Mesenchymal Stern Cells from Adult Human Bone Marrow Differentiate into a Cardiomyocyte Phenotype In Vitro
TLDR
Results indicate that 5-azacytidine can induce human MSCs to differentiate in vitro into cells with characteristics commonly attributed to cardiomyocytes, potentially valuable for repairing injured myocardium.
Human Umbilical Cord Mesenchymal Stem Cell Exosomes Enhance Angiogenesis Through the Wnt4/β‐Catenin Pathway
TLDR
Results suggest that hucMSC‐Ex‐mediated Wnt4 induces β‐catenin activation in endothelial cells and exerts proangiogenic effects, which could be an important mechanism for cutaneous wound healing.
HucMSC‐Exosome Mediated‐Wnt4 Signaling Is Required for Cutaneous Wound Healing
TLDR
It is found that hucMSC‐Ex‐treated wounds exhibited significantly accelerated re‐epithelialization, with increased expression of CK19, PCNA, collagen I (compared to collagen III) in vivo.
hucMSC Exosome-Derived GPX1 Is Required for the Recovery of Hepatic Oxidant Injury.
Exosomes-mediated transfer of long noncoding RNA ZFAS1 promotes gastric cancer progression
  • Lei Pan, W. Liang, Xu Zhang
  • Biology, Medicine
    Journal of Cancer Research and Clinical Oncology
  • 11 March 2017
TLDR
ZFas1 could be delivered by exosomes to promote GC progression, which suggests that ZFAS1 may serve as a potential diagnostic and prognostic biomarker for GC.
Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro
TLDR
The results in the present study indicate that hucMSC-ex can repair cisplatin-induced AKI in rats and NRK-52E cell injury by ameliorating oxidative stress and cell apoptosis, promoting cell proliferation in vivo and in vitro.
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