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Side population (SP) cells are an enriched source of cancer-initiating cells with stemness characteristics, generated by increased ABC transporter activity, which has served as a unique hallmark for multiple myeloma (MM) stem cell studies. Here we isolated and identified MM SP cells via Hoechst 33342 staining. Furthermore, we demonstrate that SP cells(More)
Multiple myeloma (MM) is a plasma cell neoplasm that is currently incurable. The activation of nuclear factor-κB (NF-κB) signalling plays a crucial role in the immortalisation of MM cells. As the most important transcription factor of the canonical NF-κB pathway, the p50/p65 heterodimer requires transportation into the nucleus for its successful signal(More)
Materials built from multiple constituents have revealed emerging properties that are beyond linear integration of those from single components. We report a mesoporous metal-organic framework made from three geometrically distinct metal-containing secondary building units (SBUs) as a result of topological induction. The combinations of the Cu-based(More)
A hydrogen-bonded organic framework (HOF) was constructed by avoiding potential π-π stacking of building blocks with robust and non-coplanar triptycene-based modules. The tailored-fitting interactions were demonstrated by the adsorption of fullerene with a concentration enrichment of ∼420 times in the pores.
Side population (SP) cells, a subset of enriched tumor initiating cells, have been demonstrated to have stem cell-like properties in multiple myeloma (MM) by us as well as other previous studies. A lack of agents targeting tumor initiating cells, however, represents a challenge in the treatment of MM. Previously, fenretinide, a well-tolerated vitamin A(More)
Grafting synthetic polymers to inorganic and organic surfaces to yield polymer "brushes" has represented a revolution in many fields of materials science. Polymer brushes provide colloidal stabilization to nanoparticles (NPs), prevent and/or regulate the adsorption of proteins on biomaterials, and significantly reduce friction when applied to two surfaces(More)
In vitro culture of spiral ganglion neurons (SGNs) is a useful approach to investigate numerous aspects of neuronal behavior and to identify potential therapeutic targets for SGN protection and regeneration. However, the isolation of SGNs and the long-term maintenance of their structure and function in vitro remain challenging. In this study, we isolated(More)
OBJECTIVES In this study, using an Streptococcus pneumoniae-induced tympanosclerosis (TS) model, we explored the effects of captopril and losartan in the treatment of TS and the possible mechanisms. STUDY DESIGN A prospective experimental animal study. METHODS We set up the TS models in both guinea pig and wistar rat by inoculation of type-3(More)
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