Wenqiang Liu

4Shaorong Gao
3Hong Wang
3Xiaochen Kou
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DNA methylation and demethylation have been proposed to play an important role in somatic cell reprogramming. Here, we demonstrate that the DNA hydroxylase Tet1 facilitates pluripotent stem cell induction by promoting Oct4 demethylation and reactivation. Moreover, Tet1 (T) can replace Oct4 and initiate somatic cell reprogramming in conjunction with Sox2(More)
Nucleosome organization determines the chromatin state, which in turn controls gene expression or silencing. Nucleosome remodeling occurs during somatic cell reprogramming, but it is still unclear to what degree the re-established nucleosome organization of induced pluripotent stem cells (iPSCs) resembles embryonic stem cells (ESCs), and whether the iPSCs(More)
—In the community of Linked Data, anyone can share information as Linked Data on the web because of the openness of the Semantic Web. As such, RDF (Resource Description Framework) triples that describe the same real-world entity can be obtained from multiple sources; it inevitably results in conflicting objects for a certain predicate of a real-world(More)
PURPOSE To identify the disease-causing gene in a Chinese family with autosomal dominant congenital cataract. METHODS Clinical and ophthalmologic examinations were performed on all members of a Chinese family with congenital cataract. Nine genes associated with congenital cataract were screened using direct DNA sequencing. Mutations were confirmed using(More)
Considerable effort has been made to increase the scale of Linked Data. However, because of the openness of the Semantic Web and the ease of extracting Linked Data from semi-structured sources (e.g., Wikipedia) and unstructured sources, many Linked Data sources often provide conflicting objects for a certain predicate of a real-world entity. Existing(More)
Considerable effort has been made to increase the scale of Linked Data. However, an inevitable problem when dealing with data integration from multiple sources is that multiple different sources often provide conflicting objects for a certain predicate of the same real-world entity, so-called object conflicts problem. Currently, the object conflicts problem(More)
Differentiated somatic cells can be reprogrammed into totipotent embryos through somatic cell nuclear transfer. However, most cloned embryos arrest at early stages and the underlying molecular mechanism remains largely unexplored. Here, we first developed a somatic cell nuclear transfer embryo biopsy system at two- or four-cell stage, which allows us to(More)
Transcription factor-mediated reprogramming can efficiently convert differentiated cells into induced pluripotent stem cells (iPSCs). Furthermore, many cell types have been shown to be amenable to reprogramming into iPSCs, such as neural stem cells, hematopoietic progenitor and stem cells (HPC/HSCs). However, the mechanisms related to the amenability of(More)
Mismatch repair (MMR) gene is closely related to the pathogenesis of colon cancer. This study aimed to evaluate the association between MMR status and efficacy of irinotecan-based chemotherapy. As a target of 5-FU, thymidylate synthase (TS) expression level might be influenced by irinotecan. Understanding whether this influence of TS is related with MMR(More)
Cold tolerance at the early seedling stage of rice is one of the major determinants for uniform seedling growth. The trait is complex and controlled by quantitative trait loci (QTLs). In this study, a linkage map consisting of 129 SSR markers was constructed, spanning 2,051.1 cM with ranging from 4.3 to 36.5 cM between adjacent markers. QTLs analysis at the(More)