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Cold tolerance at the early seedling stage of rice is one of the major determinants for uniform seedling growth. The trait is complex and controlled by quantitative trait loci (QTLs). In this study, a linkage map consisting of 129 SSR markers was constructed, spanning 2,051.1 cM with ranging from 4.3 to 36.5 cM between adjacent markers. QTLs analysis at the(More)
DNA methylation and demethylation have been proposed to play an important role in somatic cell reprogramming. Here, we demonstrate that the DNA hydroxylase Tet1 facilitates pluripotent stem cell induction by promoting Oct4 demethylation and reactivation. Moreover, Tet1 (T) can replace Oct4 and initiate somatic cell reprogramming in conjunction with Sox2(More)
Intracellular ISG15 is an interferon (IFN)-α/β-inducible ubiquitin-like modifier which can covalently bind other proteins in a process called ISGylation; it is an effector of IFN-α/β-dependent antiviral immunity in mice. We previously published a study describing humans with inherited ISG15 deficiency but without unusually severe viral diseases. We showed(More)
Histone modifications have critical roles in regulating the expression of developmental genes during embryo development in mammals. However, genome-wide analyses of histone modifications in pre-implantation embryos have been impeded by the scarcity of the required materials. Here, by using a small-scale chromatin immunoprecipitation followed by sequencing(More)
Histone modifications are fundamental epigenetic regulators that control many crucial cellular processes. However, whether these marks can be passed on from mammalian gametes to the next generation is a long-standing question that remains unanswered. Here, by developing a highly sensitive approach, STAR ChIP-seq, we provide a panoramic view of the landscape(More)
Nucleosome organization determines the chromatin state, which in turn controls gene expression or silencing. Nucleosome remodeling occurs during somatic cell reprogramming, but it is still unclear to what degree the re-established nucleosome organization of induced pluripotent stem cells (iPSCs) resembles embryonic stem cells (ESCs), and whether the iPSCs(More)
In the community of Linked Data, anyone can publish their data as Linked Data on the web because of the openness of the Semantic Web. As such, RDF (Resource Description Framework) triples described the same real-world entity can be obtained from multiple sources; it inevitably results in conflicting objects for a certain predicate of a real-world entity.(More)
PURPOSE To identify the disease-causing gene in a Chinese family with autosomal dominant congenital cataract. METHODS Clinical and ophthalmologic examinations were performed on all members of a Chinese family with congenital cataract. Nine genes associated with congenital cataract were screened using direct DNA sequencing. Mutations were confirmed using(More)
Considerable effort has been made to increase the scale of Linked Data. However, because of the openness of the Semantic Web and the ease of extracting Linked Data from semi-structured sources (e.g., Wikipedia) and unstructured sources, many Linked Data sources often provide conflicting objects for a certain predicate of a real-world entity. Existing(More)
Mismatch repair (MMR) gene is closely related to the pathogenesis of colon cancer. This study aimed to evaluate the association between MMR status and efficacy of irinotecan-based chemotherapy. As a target of 5-FU, thymidylate synthase (TS) expression level might be influenced by irinotecan. Understanding whether this influence of TS is related with MMR(More)