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A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy
Cancer cells frequently up-regulate DNA replication and repair proteins such as the multifunctional DNA2 nuclease/helicase, counteracting DNA damage due to replication stress and promoting survival.Expand
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YY1 suppresses FEN1 over-expression and drug resistance in breast cancer
BackgroundDrug resistance is a major challenge in cancer therapeutics. Abundant evidence indicates that DNA repair systems are enhanced after repetitive chemotherapeutic treatments, rendering cancersExpand
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Okazaki fragment maturation involves α‐segment error editing by the mammalian FEN1/MutSα functional complex
During nuclear DNA replication, proofreading‐deficient DNA polymerase α (Pol α) initiates Okazaki fragment synthesis with lower fidelity than bulk replication by proofreading‐proficient Pol δ or PolExpand
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Bone marrow stromal cells can be delivered to the site of traumatic brain injury via intrathecal transplantation in rabbits
Recent studies suggest that bone marrow stromal cells (BMSCs) are promising grafts for treatment of traumatic brain injury (TBI). Neural precursor cells (NPCs) have been detected in the site ofExpand
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Polymorphisms in three genes are associated with hemorrhagic stroke
Multiligand receptor for advanced glycation end products (RAGE), osteoprotegerin, and Golgb1 genes may be implicated in atherosclerosis and vascular diseases. Single nucleotide polymorphisms (SNPs)Expand
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TRAF6 mediates human DNA2 polyubiquitination and nuclear localization to maintain nuclear genome integrity
Abstract The multifunctional human DNA2 (hDNA2) nuclease/helicase is required to process DNA ends for homology-directed recombination repair (HDR) and to counteract replication stress. To participateExpand
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Uncovering the potential differentially expressed miRNAs as diagnostic biomarkers for hepatocellular carcinoma based on machine learning in The Cancer Genome Atlas database
The present study aimed to identify novel diagnostic differentially expressed microRNAs (miRNAs/miRs) in order to understand the molecular mechanisms underlying hepatocellular carcinoma. TheExpand
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Alberta stroke program early CT score on diffusion-weighted imaging predicts new cerebral microbleeds in patients with acute middle cerebral artery infarction
Objective To investigate the predictive value of Alberta stroke program early CT score on diffusion-weighted imaging (DWI-ASPECTS) for predicting new cerebral microbleeds (CMBs) in patients withExpand
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IDDF2018-ABS-0124 Identification of MIR-148A in plasma as a potential noninvasive biomarker for hepatocellular carcinoma
Background Detection of microRNA (miRNA) aberrations in the peripheral plasma is a new approach for hepatocellular carcinoma (HCC) screening. The aim of this study was to characterise miR-148a in theExpand