Wenling Ye

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Expression of cyclooxygenase (COX)-2, but not COX-1, in the renal medulla is stimulated by chronic salt loading; yet the functional implication of this phenomenon is incompletely understood. The present study examined the cellular localization and antihypertensive function of high-salt-induced COX-2 expression in the renal medulla, with a parallel(More)
1. Single applications of solutions of capsaicin were made to the intact skin of anaesthetized rats and the effects on cutaneous blood flow and the firing of C-nociceptor afferents determined. Blood flow was measured by laser-Doppler flowmetry. C-fibre activity was recorded from filaments dissected from the saphenous nerve. 2. Following the application of a(More)
Melanoma is a malignant tumor with high invasive and metastatic properties. Though radiation is the major therapy for melanoma, its radio-resistance has been shown to severely influence the clinical outcome. So it is imperative to enhance the sensitivity of uveal melanoma cells to radiotherapy. Previously, we found that the cell cycle of 92-1 uveal melanoma(More)
The change of cholinergic transmission of beta-amyloid protein (beta-AP) treated rats was studied by intracerebral microdialysis sampling combined with HPLC analysis. beta-AP(1-40) was injected into nucleus basalis magnocellularis (NBM). Passive avoidance response test (step-down test) and delayed alternation task were used for memory testing. The(More)
In the present work, acetylcholine(ACh) and choline(Ch) in the microdialysates from three brain areas of anesthetized rats and from hippocampus and frontal cortex of freely moving rats were simultaneously measured by high performance liquid chromatography(HPLC) with electrochemical detection combined with a post-column immobilized enzyme reactor(IMER). This(More)
In the present work, the method of microbore liquid chromatography(MLC) with dual electrode electrochemical detection (DEED) was used to determine the monoamine transmitters and their metabolites in the striatal microdialysates from the anaesthetized rats. The potentials applied on the upstream (anodic) electrode and downstream (cathodic) electrode were set(More)
Using in vivo microdialysis coupled with HPLC-fluorescent detection chemical analysis method, levels of excitatory amino acid were monitored in the caudate nucleus of rhesus monkeys (Macaca mulatta) during performance of a delayed go/no-go task in which movement or no-movement responses were executed depending on the position of a cue light. It was found(More)