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Synergistic Antitumor Effect of the Activated PPARγ and Retinoid Receptors on Human Osteosarcoma
TLDR
Activation of PPARγ, RARα, and RXRα may act synergistically on inhibiting osteosarcoma cell proliferation and tumor growth, which is at least partially mediated by promoting osteoblastic differentiation of osteosARcoma cells. Expand
Establishment and quality evaluation of a glioma biobank in Beijing Tiantan Hospital
TLDR
Storage conditions of the glioma biobank are suitable for long-term sample preservation with high molecular quality. Expand
Investigation of the urinary metabolic variations and the application in bladder cancer biomarker discovery
TLDR
The study showed that urinary metabolomics is a useful strategy for differential analysis and biomarker discovery in bladder cancer patients using liquid chromatography coupled with high resolution mass spectrometry. Expand
Augmenting the therapeutic efficacy of adenosine against pancreatic cancer by switching the Akt/p21-dependent senescence to apoptosis
TLDR
The data confirmed the therapeutic effect of adenosine on pancreatic cancer, and revealed the potential of Akt inhibitors as sensitization agents in this treatment. Expand
Targeting high Aurora kinases expression as an innovative therapy for hepatocellular carcinoma
TLDR
These findings indicated Aurora kinases/YAP/P21 was an oncogenic signaling axis in HCC, and revealed targeting Aurora AHBH induced apoptosis by YAP suppression, providing a solid evidence for SNS-314 as a potential targeted therapy, and a proof-of-concept evidence for a possible combined therapy of S NS-314 plus Hippo pathway inhibitors on HCC. Expand
Suppression of AURKA alleviates p27 inhibition on Bax cleavage and induces more intensive apoptosis in gastric cancer
TLDR
It is found that MNL8237 suppressed cell growth by regulating calpain-dependent Bax cleavage and p27 dysregulation in gastric cancer cells. Expand
Skeletal Muscle CLARITY: A Preliminary Study of Imaging The Three-Dimensional Architecture of Blood Vessels and Neurons
TLDR
It is concluded that this passive CLARITY protocol can be successfully applied to three-dimensional cellular and whole muscle imaging in mice, and will facilitate structural analyses and connectomics of large assemblies of muscle cells, vessels and neurons in the context of three- dimensional systems. Expand
Targeting of the C-Jun/BCL-XL/P21 Axis Accelerates the Switch from Senescence to Apoptosis Upon ROC1 Knockdown in Gastric Cancer Cells
TLDR
High ROC1 expression was correlated with poor prognosis and a low 5-year survival rate of gastric cancer patients and the c-Jun/BCL-XL/p21 axis promotes senescence to resist Roc1 knockdown-induced apoptosis in Gastric cancer cells. Expand
Targeting CAND1 promotes caspase-8/RIP1-dependent apoptosis in liver cancer cells.
TLDR
This study pioneered in reporting high CAND1 expression as a predictor of poor prognosis for HCC patients and supported that CAND 1 could be a new therapeutic target for liver cancer. Expand
MAT2B mediates invasion and metastasis by regulating EGFR signaling pathway in hepatocellular carcinoma
TLDR
This study showed that both in the xenograft zebra fish model and in the lung metastasis model in nude mice, the stable inhibition of MAT2B could suppress the metastasis of HCC cancer cells and suggested that MAT2 B might serve as a new prognostic marker and therapeutic target for HCC. Expand
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