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Background Oxidative stress is considered to have a causative role in the development of central nervous system diseases, such as Alzheimer’s disease, Parkinson’s disease, tumor, etc. Curcumin, a polyphenol extracted from rhizomes of the plant Curcuma longa, is widely reported to have diverse anti-oxidative stress effects, but the underlying mechanism has(More)
The APPswe plasmid was transfected into the neuroblastoma cell line SH-SY5Y to establish a cell model of Alzheimer's disease. Graded concentration and time course experiments demonstrate that curcumin significantly upregulates phosphatidylinositol 3-kinase (PI3K), Akt, nuclear factor E2-related factor-2 (Nrf2), heme oxygenase 1 and ferritin expression, and(More)
Background The deprivation or abnormality of the molecular function of Wnt/b-catenin triggers the genesis and development of AD, and b-catenin is an important positive mediator in the Wnt/b-catenin signaling pathway. In our previous study, we found that Curcumin could inhibit the expression of b-catenin and prevent AD, but the mechanisms were not fully(More)
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