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The peptide antibiotic ramoplanin factor A2 is a promising clinical candidate for treatment of Gram-positive bacterial infections that are resistant to antibiotics such as glycopeptides, macrolides, and penicillins. Since its discovery in 1984, no clinical or laboratory-generated resistance to this antibiotic has been reported. The mechanism of action of(More)
—In remote-sensing classification, there are situations when users are only interested in classifying one specific land-cover type, without considering other classes. These situations are referred to as one-class classification. Traditional supervised learning is inefficient for one-class classification because it requires all classes that occur in the(More)
This study aims to quantify the effects of topographic variability (measured by coefficient variation of elevation, CV) and lidar (Light Detection and Ranging) sampling density on the DEM (Digital Elevation Model) accuracy derived from several interpolation methods at different spatial resolutions. Interpolation methods include natural neighbor (NN),(More)
The etiology of osteoarthritis (OA) is complex and multifaceted. Osteoarthritis is a chronic and progressive disease of the joints that is characterized by the degradation of articular cartilage. A disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5) is the major aggrecanase in cartilage. The aim of this study was to evaluate the effect(More)
Tau is a microtubule-associated protein that promotes microtubule assembly and stability. In Alzheimer's disease and related tauopathies, tau fibrillizes and aggregates into neurofibrillary tangles. Recently, oleocanthal isolated from extra virgin olive oil was found to display non-steroidal anti-inflammatory activity similar to ibuprofen. As our(More)
Tau proteins are building blocks of the filaments that form neurofibrillary tangles of Alzheimer's disease (AD) and related neurodegenerative tauopathies. It was recently reported that two VQIXXK motifs in the microtubule (MT) binding region, named PHF6 and PHF6*, are responsible for tau fibrillization. However, the exact role each of these motifs plays in(More)
Efforts are underway at the Centers for Disease Control and Prevention to foster greater use of electronic data stored in health care application databases for surveillance of health care-associated infections and antimicrobial use and resistance. These efforts, referred to as the National Healthcare Safety Network (NHSN) eSurveillance Initiative, focus on(More)