Tau proteins are building blocks of the filaments that form neurofibrillary tangles of Alzheimer's disease (AD) and related neurodegenerative tauopathies. It was recently reported that two VQIXXK motifs in the microtubule (MT) binding region, named PHF6 and PHF6*, are responsible for tau fibrillization. However, the exact role each of these motifs plays in… (More)
Light detection and ranging (lidar) data is increasingly being used for ecosystem monitoring across geographic scales. This work concentrates on delineating individual trees in topographically-complex, mixed conifer forest across the California's Sierra Nevada. We delineated individual trees using vector data and a 3D lidar point cloud segmentation… (More)
BACKGROUND Pneumonia is a leading infectious disease killer worldwide, yet the burden in China is not well understood as much of the data is published in the non-English literature. METHODOLOGY/PRINCIPAL FINDINGS We systematically reviewed the Chinese- and English-language literature for studies with primary data on pneumonia incidence and mortality in… (More)
After recreational exposure to river water in Uganda, 12 (17%) of 69 persons had evidence of schistosome infection. Eighteen percent self-medicated with praziquantel prophylaxis immediately after exposure, which was not appropriate. Travelers to schistosomiasis-endemic areas should consult a travel medicine physician.
The Shuttle Radar Topography Mission (SRTM) digital elevation model (DEM) is one of the most complete and frequently used global-scale DEM products in various applications. However, previous studies have shown that the SRTM DEM is systematically higher than the actual land surface in vegetated mountain areas. The objective of this study is to propose a… (More)