Wenjun Tang

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The molecular structure of azaspiracid-1, a neurotoxin isolated from mussels, has been elucidated by total synthesis which also enriched its supplies. The degradatively derived fragments of this marine biotoxin, compounds 5 (EFGHI), 6 (FGHI), and 40 (ABCD), were matched with synthetic materials, thus confirming their structural identities. Based on this(More)
Efficient asymmetric Suzuki-Miyaura coupling reactions are employed for the first time in total syntheses of chiral biaryl natural products korupensamine A and B in combination with an effective diastereoselective hydrogenation, allowing ultimately a concise and stereoselective synthesis of michellamine B. Chiral monophosphorus ligands L1-3 are effective(More)
A series of novel P-chiral monophosphorus ligands exhibit efficiency in asymmetric Suzuki-Miyaura coupling reactions, enabling the construction of an array of chiral biaryl products in high yields and excellent enantioselectivities (up to 96% ee) under mild conditions. The carbonyl-benzooxazolidinone moiety in these chiral biaryl products allows facile(More)
[1] A multi-scale soil moisture and temperature monitoring network, consisting of 55 soil moisture and temperature measurement stations, has been established in central Tibetan Plateau (TP). In this study, the station-averaged surface soil moisture data from the network are used to evaluate four soil moisture products retrieved from the Advanced Microwave(More)
The key building blocks (6, 7, and 8) for the intended construction of the originally proposed structures of azaspiracid-1, a potent marine-derived neurotoxin, were coupled and the products elaborated to the targeted compounds (1a,b) and their C-20 epimers (2 and 3). The assembly of the three intermediates was accomplished by a dithiane-based coupling(More)
—The land surface on the Tibetan Plateau (TP) experiences diurnal and seasonal freeze/thaw processes that play important roles in the regional water and energy exchanges, and passive microwave satellites provide opportunities to detect the soil state for this region. With the support of three soil moisture and temperature networks on the TP, a dual-index(More)