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Heterogeneous organization of the locus coeruleus projections to prefrontal and motor cortices
TLDR
The consensus view of LC as a relatively homogeneous modulator of forebrain activity is challenged by demonstrating that neurons in the locus coeruleus maintain segregated connections to brain regions with distinctly different functions, and the impact of the system on the generation and maintenance of adaptive and maladaptive behaviors.
Role of dysbindin in dopamine receptor trafficking and cortical GABA function
TLDR
It is suggested that dysbindin regulates PFC function by facilitating D2-mediated modulation of GABAergic function.
Cell-type Specific Development of NMDA Receptors in the Interneurons of Rat Prefrontal Cortex
TLDR
Fast-spiking interneurons in the prefrontal cortex undergo dramatic changes in glutamatergic receptors during the adolescent period, which may make FS cells particularly sensitive and vulnerable to epigenetic stimulation, thus contributing to the onset of many psychiatric disorders, including schizophrenia.
A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortex
TLDR
It is found that NMDA receptor-mediated currents at prefrontal synapses in the adult, but not young, rats exhibit a twofold longer decay time-constant and temporally summate a train of stimuli more effectively, compared to those in the primary visual cortex.
Dopamine Modulation of Perisomatic and Peridendritic Inhibition in Prefrontal Cortex
TLDR
Paired whole-cell recording is used to study the influence of dopamine on local inhibitory circuits involving fast-spiking (FS) and non-FS cells to provide evidence for both a dual mode of inhibition in prefrontal circuitry and circuit-dependent modulation by dopamine.
Activation of Glycogen Synthase Kinase-3β Is Required for Hyperdopamine and D2 Receptor-Mediated Inhibition of Synaptic NMDA Receptor Function in the Rat Prefrontal Cortex
TLDR
The results suggest that GSK-3β is required for the hyperdopamine/D2 receptor-mediated inhibition of NMDA receptors in the prefrontal neurons and these actions may underlie D2 receptors-mediated psychostimulant effects and hyperdipamine-dependent behaviors in the brain.
Selective modulation of excitatory and inhibitory microcircuits by dopamine
TLDR
Dopamine's effects on excitatory transmission are target-specific and that the axon terminals of pyramidal neurons can be selectively regulated at the level of individual synapses, indicating that dopamine's net inhibitory effect on cortical function is remarkably constrained by the nature of the microcircuit elements on which it acts.
Development of calcium‐permeable AMPA receptors and their correlation with NMDA receptors in fast‐spiking interneurons of rat prefrontal cortex
TLDR
The data suggest that CP‐AMPARs in FS interneurons may play a critical role in neuronal integration and that their characteristic properties may make these cells particularly vulnerable to disruptive influences in the PFC, thus contributing to the onset of many psychiatric disorders.
PV Interneurons: Critical Regulators of E/I Balance for Prefrontal Cortex-Dependent Behavior and Psychiatric Disorders
TLDR
In this review, growing evidence supports a fundamental role of fast-spiking parvalbumin (PV) GABAergic interneurons in regulating pyramidal neuron activity to drive appropriate behavioral responses and speculation on whether this circuitry could represent a platform for the development of therapeutic interventions in disorders of PFC function.
Dizocilpine (MK-801) induces distinct changes of N-methyl-D-aspartic acid receptor subunits in parvalbumin-containing interneurons in young adult rat prefrontal cortex.
TLDR
The results suggest that PV-containing interneurons in the PFC exhibit a distinct responsiveness to NMDAR antagonism and that NMDA antagonist can differentially and dose-dependently regulate the functions of pyramidal neurons and GABAergic interneurs in the prefrontal cortical circuitry.
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