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Rex-1 (Zfp-42) is a known marker for undifferentiated embryonic stem cells and teratocarcinoma cells. However, the mechanism by which Rex-1 is regulated in pluripotent cells remains unresolved. Here we report that Nanog, an Nk-2 homeodomain protein known for its role in maintaining stem cell pluripotency, is a transcription activator for the Rex-1 promoter.(More)
/ sciencemag.org/content/early/recent / 26 November 2015 / Page 1 / 10.1126/science.aad5761 Current international climate negotiations seek to catalyze global emissions reductions through a system of nationally determined country-level emissions reduction targets that would be regularly updated. These “Intended Nationally Determined Contributions” (INDCs)(More)
Islet neogenesis associated protein (INGAP) promotes the generation of new islet mass in adult animal models. It is not understood what factors control the expression of INGAP. In this study, factors that regulate the expression of INGAP promoter activity are reported. To determine factors that regulate INGAP expression, we previously cloned the promoter(More)
The protein product of hamster islet neogenesis-associated protein (INGAP) cDNA induces new pancreatic islet development. Manipulation of this process provides a new therapeutic strategy for the treatment of diabetes. As regulators of INGAP gene expression are unknown over 6 kb of hamster genomic INGAP has been cloned. Sequence analysis has identified a 3(More)
An evoked-potential audiogram was measured for an Indo-Pacific humpback dolphin (Sousa chinensis) living in the dolphinarium of Nanning Zoo, China. Rhythmic 20 ms pip trains composed of cosine-enveloped 0.25 ms tone pips at a pip rate of 1 kHz were presented as sound stimuli. The dolphin was trained to remain still at the water surface and to wear soft(More)
BACKGROUND Non-productive cellulase adsorption onto lignin has always been deemed to negatively affect the enzymatic hydrolysis of lignocellulosic feedstocks. Therefore, understanding enzyme-lignin interactions is essential for the development of enzyme mixtures, the processes of lignocellulose hydrolysis, and the genetic modification of lignocellulosic(More)
OBJECTIVE Islet neogenesis-associated protein (INGAP) can enhance beta-cell mass to offset progression of diabetes. Identifying how transcription factors regulate INGAP gene expression could reveal key checkpoints governing islet neogenesis. METHODS Protein complex interactions at the INGAP promoter were detected using a beta-galactosidase reporter, these(More)
Broadband recording systems were adapted to characterize the whistle characteristics of free-ranging Indo-Pacific humpback dolphins (Sousa chinensis) in Sanniang Bay, China. A total of 4630 whistles were recorded, of which 2651 with legible contours and relatively good signal-to-noise ratios were selected for statistical analysis. Of the six tonal types(More)
Haemophilus parasuis is the causative agent of Glässer's disease, which leads to serious economic loss to the swine industry. Although antibiotics are widely used to control infections, outbreaks of this disease repeatedly happen. In this study, emodin from Polygonum cuspidatum showed potent inhibitory effect against H. parasuis. The minimal inhibitory(More)
Nitrogen/sulfur co-doped anatase TiO2 nanocrystals with a high specific surface area and a high percentage of {001} facets were synthesized by a solvent-thermal process followed by the calcination with thiourea at an optimum heat treatment temperature. Under current experimental conditions, the optimum heat treatment temperature was found at 300°C, which(More)