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In Caenorhabditis elegans (C. elegans), the promotion of longevity by the transcription factor DAF-16 requires reduced insulin/IGF receptor (IIR) signaling or the ablation of the germline, although the reason for the negative impact of germ cells is unknown. FOXO/DAF-16 activity inhibits germline proliferation in both daf-2 mutants and gld-1 tumors. In(More)
Correlative evidence links stress, accumulation of oxidative cellular damage, and aging in several species. Genetic studies in species ranging from yeast to mammals revealed several pathways regulating stress response and life span, including caloric intake, mitochondrial respiration, insulin/IGF-1 (IIS), and JNK (c-Jun N-terminal kinase) signaling. How IIS(More)
DNA double-strand breaks (DSBs) are a type of lethal DNA damage. The repair of DSBs requires tight coordination between the factors modulating chromatin structure and the DNA repair machinery. BRG1, the ATPase subunit of the chromatin remodelling complex Switch/Sucrose non-fermentable (SWI/SNF), is often linked to tumorigenesis and genome instability, and(More)
The great success of electrochemiluminescence (ECL) for in vitro diagnosis (IVD) and its promising potential in light-emitting devices greatly promote recent ECL studies. More than 45% of ECL articles were published after 2010, and the first international meeting on ECL was held in Italy in 2014. This critical review discusses recent vibrant developments in(More)
This paper addresses flower image classification. The extent of blossom, deformation and inter-class appearance blur of flowers add great difficulties to flower classification task in addition to view, color, illumination changes that commonly occurred in other objects classification tasks. In this paper, SIFT-like feature descriptors and feature context(More)
Actin, one of the most evolutionarily conservative proteins in eukaryotes, is distributed both in the cytoplasm and the nucleus, and its dynamics plays important roles in numerous cellular processes. Previous evidence has shown that actin interacts with p53 and this interaction increases in the process of p53 responding to DNA damage, but the physiological(More)
The quenching of electrochemiluminescence by single-walled carbon nanohorn has been demonstrated for the first time. Moreover, a sensitive, label-free, and signal-on electrochemiluminescence ATP aptasensor was developed using single-walled carbon nanohorn as both quencher and scaffold.
Both the electrochemiluminescence (ECL) method for sensitive detection of ozone and the ECL resonance energy transfer (ECRET) using ozone have been reported for the first time. It is based on the ECRET of Ru(phen)3(2+)-doped silica nanoparticles (RuSiNPs) to indigo carmine. In the absence of ozone, the ECL of RuSiNPs is quenched as a result of the ECRET of(More)
Owing to its high affinity with phosphate, Zr(IV) can induce the aggregation of adenosine 5'-triphosphate (ATP)-stabilized AuNPs, leading to the change of surface plasmon resonance (SPR) absorption spectra and color of ATP-stabilized AuNP solutions. Based on these phenomena, visual and SPR sensors for Zr(IV) have been developed for the first time. The A(660(More)
Atrial tissue gene expression profiling may help to determine how differentially expressed genes in the human atrium before cardiopulmonary bypass (CPB) are related to subsequent biologic pathway activation patterns, and whether specific expression profiles are associated with an increased risk for postoperative atrial fibrillation (AF) or altered response(More)