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BACKGROUND Contribution of cardiovascular disease related genetic risk factors for stroke are not clearly defined. We performed a genetic association study to assess the association of 56 previously characterized gene variants in 34 candidate genes from cardiovascular disease related biological pathways with ischemic stroke and cerebral hemorrhage in a(More)
Cisplatin is one of the most effective antitumor drugs for non-small cell lung carcinoma (NSCLC) patients. However, its efficacy has encountered a plateau due to its side effects and drug resistance. Inducible nitric oxide (NO) synthase (iNOS) gene therapy has been reported to have antitumor effects in several types(More)
This study was aimed to shed light on the biological and pharmaceutical characterization of the complexes of FUS1/hIL-12 double gene with cationic liposome, and to assess such complexes' transfection efficiency, stability and cytotoxicity; for they have the potential for use as drugs in gene therapy of lung cancer. Gel retardation assay, diameter(More)
LKB1 and FUS1 are two kinds of new tumor suppressor genes as well as early-stage genes in lung cancer. Recent studies showed that LKB1 and FUS1 play important roles in lung carcinogenesis process. We hypothesized that combined gene therapy with LKB1 and FUS1 could inhibit lung cancer growth and development synergistically. In this study, two kinds of tumor(More)
A new flavonoid glycoside, named tricin-7-O-(β-glucuronide-6″-butyl ester) (1), together with ten known compounds, including five flavonoids (2–6), three triterpenoids (7–9), one iridoid glycoside (10), and one phytosterol (11), were isolated from the whole herb of Dodartia orientalis L. Their structures were elucidated on the basis of spectroscopic(More)
BACKGROUND KCNK17 (potassium channel, subfamily K, member17) has a role in the pathogenesis of stroke. We reported previously that rs10947803 single-nucleotide polymorphism (SNP) in KCNK17 is associated with cerebral hemorrhage in a Chinese population. The aim of the present study was to examine other SNPs in the KCNK17 gene that are associated with(More)
OBJECTIVE To investigate the association between cigarette smoking and ischemic stroke. METHODS A case-control study was conducted. Investigators got the available information from the cases and controls by questionnaires. Logistic regression models were used to analyze the relationship between smoking and ischemic stroke in this study. RESULTS A total(More)
BACKGROUND AND OBJECTIVE The iNOS gene is associated with NO-mediated antitumor effects. The aims of this study are to construct a eukaryotic expression plasmid that carries the iNOS gene and to detect the expression levels and antitumor effects of the iNOS gene on A549 lung cancer cells. METHODS A DNA fragment of the human iNOS coding sequence was(More)
OBJECTIVE To explore the relationship between blood pressure variability and worsening functional outcomes of patients upon discharge from the hospitals. METHODS The study cohort consisted of 404 patients who presented to Second Affiliated Hospital of Harbin Medical University with ischemic stroke during March 2012-March 2013. Systolic BP and diastolic BP(More)
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